Sun et al: Mifepristone Pretreatment before Laparoscopic Myomectomy To observe and analyze the clinical outcome of mifepristone pretreatment before laparoscopic myomectomy, 180 patients who underwent laparoscopic myomectomy at the Shuyang Hospital of Traditional Chinese Medicine were enrolled in a clinical study. These patients were divided into the research and the control groups based on different therapeutic regimens received with 90 patients in each group. Of those, patients in the control group underwent normal laparoscopic myomectomy, while patients in the research group received mifepristone pretreatment before laparoscopic myomectomy. The clinical outcomes were observed and compared. A comparison of the surgical time, blood loss and intraoperative blood transfusion rate, revealed that the above indices were significantly better in the research group compared to those of the control group (p<0.05). Moreover, the post-operative pain scores of the research group were significantly lower than that of the control group (p<0.05). However, the short term clinical efficacy was not of significant difference between both groups. Pretreatment with mifepristone before laparoscopic myomectomy could gain ideal therapeutic efficacy and reduce the intraoperative blood loss and blood transfusion rate, which would make this therapeutic approach safer and more reliable.