Facile methods to improve the dissolution rate of poorly water-soluble drugs are highly sought after. In this study, a modified coaxial electrospinning process was exploited to create medicated amorphous nanocomposites, an approach characterized by the application of a Teflon-coated coaxial spinneret. The hydrophilic polymer hydroxypropyl methylcellulose and the active ingredient tamoxifen citrate (TAM) were selected as the drug carrier and model drug, respectively. Their electrospun nanocomposites showed linear morphology with the drug presented in an amorphous state. The loaded cargoes could be released from the nanocomposites simultaneously when they were placed in the dissolution media, showing faster dissolution rates than their counterparts (physical mixtures). Based on the reasonable application of the polymeric carrier, the reported protocols not only provided an approach to enhance the dissolution of poorly water-soluble drugs, but also exhibited a method to facilitate the implementation of coaxial electrospinning.

Under high-speed and heavy-load conditions, the influence of temperature on the gear system is extremely important. Basically, the current work on the effect of temperature mostly considers the flash temperature or the overall temperature field to cause expansion at the meshing point and then affects nonlinear factors such as time-varying meshing stiffness, which lead to the deterioration of the dynamic transmission. This work considers the effect of temperature on the material’s elastic modulus and Poisson’s ratio and relates the temperature to the time-varying meshing stiffness. The effects of temperature on the elastic modulus and Poisson’s ratio are expressed as functions and brought into the improved energy method stiffness calculation formula. Then, the dynamic characteristics of the gear system are analyzed. With the bifurcation diagram, phase, Poincaré, and fast Fourier transform plots of the gear system, the influence of temperature on the nonlinear dynamics of the gear system is discussed. The numerical analysis results show that as the temperature increases, the dynamic response of the system in the middle-speed region gradually changes from periodic motion to chaos.

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