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Abstract. College students' entrepreneurship has been widespread concern and support from all sectors of society. But on the whole, the success rate of College Students' entrepreneurship is low. It is a waste of valuable resources such as time and money. Aiming at the problem, this questionnaire takes 200 college students entrepreneurial enterprises in Wuhan City as a sample. Discuss from dimensions such as companies, government, colleges and universities. Analyze the factors that influence the success of College Students' Entrepreneurship innovatively. Get the driving factors and obstacles to its success. The study found that set up the college students' entrepreneurship support platform by government, constructing the system of Cultivating College Students' entrepreneurial ability, make full use of industry-university interaction in the promotion role and strengthen the construction of enterprise internal environment are effective countermeasures. Provide a reference for college students successful entrepreneurship.