Drug-induced liver injury (DILI) due to prescription, over-thecounter and herbal products is a major cause of liver disease around the world. 1,2 Diagnosis of DILI is challenging because there is no single clinical, laboratory or histologic feature specific to DILI. Accurate diagnosis requires establishing a causal relationship withthe suspected agent and excluding competing causes of liver injury. Pharmacy monitoring is an essential component in the management of DILI by offering clues to the underlying pathogenesis, providing prognostic information and guiding therapy. 3 Amiodarone is a class III antiarrhythmic agent used to treat atrial and ventricular arrhythmias, including atrial flutter and fibrillation. 4 DILI due to oral amiodarone was extensively studied. However, the available data regarding acute hepatotoxicity form intravenous amiodarone are rare case report. 5 Severe hepatitis secondary to amiodarone is rare and potentially fatal. The case presented here contributes to the limited clinical experience with acute liver injury to intravenous amiodarone.