The transformations that allow the direct removal of hydrogen from their corresponding saturated counterparts by dehydrogenative strategy is a dream reaction that has remained largely underexplored. In this report, a...

The construction of molecular skeletons and modification of molecules using widely available and easily prepared alcohols as radical precursors for coupling reactions are significant and challenging subjects. We herein report a straightforward strategy for the dehydrogenative ring-opening alkenylation of cycloalkanols with alkenes by combining a proton-coupled electron transfer strategy and a dual photoredox and cobalt catalysis system. With this approach, a series of distally unsaturated ketones were obtained in 17−83% yields with high E selectivity.

Direct C-H/N-H dehydrogenative coupling is a promising yet thermodynamically unfavorable transformation in the absence of sacrificial hydrogen acceptor. Herein, a conceptually novel oxidant-free dehydrogenative amination of alkenes through a synergistic...