Bacteria preferentially accumulating in tumor microenvironments can be utilized as natural vehicles for tumor targeting. However, neither current chemical nor genetic approaches alone can fully satisfy the requirements on both stability and high efficiency. Here, we propose a strategy of “charging” bacteria with a nano-photocatalyst to strengthen their metabolic activities. Carbon nitride (C3N4) is combined with Escherichia coli (E. coli) carrying nitric oxide (NO) generation enzymes for photo-controlled bacterial metabolite therapy (PMT). Under light irradiation, photoelectrons produced by C3N4 can be transferred to E. coli to promote the enzymatic reduction of endogenous NO3– to cytotoxic NO with a 37-fold increase. In a mouse model, C3N4 loaded bacteria are perfectly accumulated throughout the tumor and the PMT treatment results in around 80% inhibition of tumor growth. Thus, synthetic materials-remodeled microorganism may be used to regulate focal microenvironments and increase therapeutic efficiency.

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In this paper, we examine the influence of foreign direct investment (FDI) on Chinese industrial carbon emission through technical channels. Based on data from Chinese 35 industrial sectors during 1999-2008, and using the different indicators which represent diverse technical effects channels, we investigate technology effects of FDI on Chinese industrial carbon emission. Results show that FDI do bring positive influence on Chinese carbon emission in industrial sectors through technical channels and these effects of FDI reach maximum one year later.