Using a combination of CYP2C19 genotype and postoperative time to determine the initial voriconazole dosing regimens followed by therapeutic drug monitoring could help to advance individualized treatment in renal transplantation patients with invasive fungal infections.

Enantiomeric 3-Arylcoumarins and 2-Arylcoumarones from the Roots of Glycyrrhiza uralensis as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors. -All compounds show significant inhibitory activities against PTP1B. Compound (IV) also displays cytotoxicity against human cancer cell lines SW480 (colorectal adenocarcinoma), HepG2 (liver carcinoma) and A549 (alveolar adenocarcinoma). Aside (IV), only ((R)-I) shows some cytotoxic effects in the assays. -(JI, S.; QIAO, X.; LI, Z.-W.; WANG, Y.-R.; YU, S.-W.; LIANG, W.-F.; LIN, X.-H.; YE*, M.; RSC Adv. 5 (2015) 56, 45258-45265, http://dx.doi.org/10.1039/C5RA06452J ; State Key Lab. Nat. Biomimetic Drugs, Sch. Pharm. Sci., Peking Univ., Beijing 100191, Peop. Rep. China; Eng.) -M. Tismer 41-229