C−H bond functionalization generates molecular complexity in single‐step transformation. However, the activation of C−H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species. In many cases, they often require pre‐functionalization of starting molecules. Such pre‐activating measures cause waste generation and their separation from the final product is also troublesome. In such a scenario, reactions activating elements generating from renewable energy resources such as electricity and light would be more efficient, green, and cost‐effective. Further, incorporation of growing flow technology in chemical transformation processes will accelerate the safer accesses of valuable products. Arenes & heteroarenes are ubiquitous in pharmaceuticals, natural products, medicinal compounds, and other biologically important molecules. Herein, we discussed enabling tools and technologies used for the recent C−H bonds functionalization of arenes and heteroarenes.

C-H bond functionalization generates molecular complexity in single-step transformation. However, the activation of C-H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species. In many cases, they often require pre-functionalization of starting molecules. Such pre-activating measures cause waste generation and their separation from the final product is also troublesome. In such a scenario, reactions activating elements generating from renewable energy resources such as electricity and light would be more efficient, green, and cost-effective. Further, incorporation of growing flow technology in chemical transformation processes will accelerate the safer accesses of valuable products. Arenes & (hetero) arenes are ubiquitous in pharmaceuticals, natural products, medicinal compounds, and other biologically important molecules. Herein, we discussed enabling tools and technologies used for the recent C–H bonds functionalization of Arenes / (Hetero)Arenes.

The electrochemical generation of molecular complexity via CH bond transformations without pre-functionalization of molecules, stoichiometric amounts of oxidizing/reducing species or precious metal catalysts, represent a highly sustainable technology and green methodology of contributing toward resource economy. Thus, renewable electricity provides clean electron (oxidant/reductant) that initiate a reaction cascade via producing reactive intermediates that facilitate in the building of new bonds for valuable chemical transformations. The application of modern enabling strategies (electrochemistry, photochemistry & microfluidics) in organic transformations will accelerate the process to achieve sustainable CH bond activation and to access valuable chemicals, pharmaceuticals, and fine chemicals under safe & environmentally friendly conditions. Herein, we discussed enabling tools and technologies used for the recent CH bonds functionalization of Arenes / (Hetero)Arenes.