Context: Quercetin (que) is one abundant flavonol with a variety of biological activities. Previous studies have shown quercetin can reduce neuropathic pain in rats with chronic constriction injury (CCI). Objective: To evaluate the effects of quercetin on neuropathic pain in CCI model and explore its underlying mechanism in vivo. Materials and Methods: CCI model was established by ligating the sciatic nerve of right leg on the SD rats. They were divided into ten groups: sham group, CCI model, sham+ que, CCI+ que group (30, 60, 120 mg/kg), CCI+ AICAR, CCI+ que+ compound C, CCI+etoricoxib, and the control group. They were administered for 28 days, and were performed the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) during the experiment. At the end of the experiment, sciatic nerves and spinal cord segments of rats were collected, ELISA detected the expression of inflammatory factors, detected the microglia and astrocytes with fluorescence, and Western blot detected AMPK/MAPK pathway. Results: Que could increase the MWT of CCI rats, improve the TWL of plantar, and reduce the inflammatory cells at the ligation site of the sciatic nerve. Also, que could reduce the levels of TNF-α, IL-6, and IL-1β. Western blotting results showed that p-38 MAPK, p-ERK, and p-JNK were activated in the spinal dorsal horn of CCI model group. After treatment with que and AMPK agonists, the phosphorylation levels of related proteins were inhibited. In addition, the analgesic effect of que was abolished when the AMPK inhibitor was added. Discussion and Conclusion: Quercetin alleviated the inflammatory response of sciatic nerve and spinal dorsal horn in rats induced by CCI. Quercetin alleviates neuralgia in CCI rats by activating AMPK pathway and inhibiting MAPK pathway and its downstream targets, p-38, p-ERK, and p-JNK.

Over the past decade, the total amount of Foreign Direct Investment (FDI) has fluctuated constantly with China as the leading recipient of FDI. The World Investment Report of 2020 shows that, looking back at 2019, FDI flows to developing Asian economies fell 5 percent to $474 billion. However, Asia remains the world's largest recipient of FDI, with more than 30 percent of global FDI inflows in 2019. Moreover, China's absorption of FDI reached 141 billion in 2020 at record highs [1]. With the influx of FDI, China has implemented a negative list system for market access and strengthened the Foreign Investment Security Review (FISR) to improve investment facilitation while ensuring national security. Conclusively, whether from the perspective of China's investment situation, system construction, or the international situation, it is of great significance to analyze the FISR based on the currently effective regulations in China. This paper will point out the problems hidden in the current FISR from aspects of review subjects and division of authority, the criteria of review, and specific procedure, then provide practical and valuable improvements in response to the above problems. This not only makes up for the deficiencies of the relevant legal system in China but also provides a reasonable reference for the optimization of the relevant legal system in the world.