Breast cancer is one of the most
common malignant tumors in women.
The existence of multiple breast cancer subtypes often leads to chemotherapy
failure or the development of drug resistance. In recent years, photodynamic
therapy has been proven to enhance the sensitivity of tumors to chemotherapeutic
drugs. Porphyrin-based metal–organic framework (MOF) materials
could simultaneously be used as carriers for chemotherapy and photosensitizers
in photodynamic therapy. In this paper, doxorubicin hydrochloride
(DOX) was loaded in porphyrin MOFs, and the mechanism of the synergistic
effect of the DOX carriers and photodynamic therapy on breast cancer
was investigated. In vitro and in vivo experiments have shown that
MOFs could prolong the residence time of DOX in tumor tissues and
promote the endocytosis of DOX by tumor cells. In addition, adjuvant
treatment with photodynamic therapy can promote breast cancer tumors
to resensitize to DOX and synergistically enhance the chemotherapy
effect of DOX. Therefore, this study can provide effective development
ideas for reversing drug resistance during breast cancer chemotherapy
and improving the therapeutic effect of chemotherapy on breast cancer.
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