Background: Numerous clinical studies have shown that atopic dermatitis (AD) is often associated with mental disorders. This could contribute to the overall burden of atopic dermatitis. However, the underlying mechanism of mental health symptoms in AD has not been fully elucidated.Methods: An AD mouse was induced by 2,4-dinitrofluorobenzene (DNFB), which was repeatedly applied to the back skin of the BALB/C mice to establish an atopic dermatitis mental disorder model. The role of neuroinflammation in the pathogenesis of atopic dermatitis mental disorders was then explored.Results: After the stimulation of DNFB for 35 days, the skin lesions, the HE staining of skin lesions, and the behavioral experiments (including elevated plus maze assay and tail suspension test) suggested that the AD mental disorder mouse model was successfully replicated. The expression of neuroinflammatory factors in the hippocampus was then investigated through Western blotting. The results showed a significant increase in the protein expression of NLRP3, caspase-1, and IL-1β.Conclusion: Mental disorders in AD might be related to the neuroinflammatory response in the hippocampus. An alternative yet essential approach to promoting AD recovery could be through reducing neuroinflammation and improving mental disorders.

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This paper considers an evasion maneuver for low-altitude aircraft (A/C) in the presence of the threat of a guided missile. The missile has boost and sustain phases and its trajectory is estimated by a 7-D motion parameter vector. The maximum likelihood estimator is used to estimate the missile motion parameters based on angle measurements from an A/C-borne passive sensor. Based on the estimated closest point of approach distance between the missile and the aircraft, a warning alert is then given to execute an evasion maneuver. The aircraft can bank away from the missile by a turning maneuver in the horizontal plane. Simulation shows that the aircraft can evade the missile by using the turning maneuver. The survivability probability of the aircraft is evaluated and it can be enhanced by an early maneuver start time and a large acceleration during the maneuver.