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In this study, the data on solid−liquid equilibrium of L-prolinamide were studied using the gravimetric method. The solubility of L-prolinamide was measured in ten pure solvents (tetrahydrofuran, n-heptane, n-propanol, acetone, acetonitrile, ethyl acetate, N,N-dimethylformamide, n-hexane, cyclohexane, and isopropanol) and three binary solvent mixtures(ethyl acetate + tetrahydrofuran, n-heptane + ethyl acetate, and n-hexane + acetone) in the temperature range of 278.15−323.15 K at atmospheric pressure. The experimental values showed that the solubility increased with the increase of temperature in all solvents. The solubility data in different pure solvents were fitted using the modified Apelblat model and the Buchowski−Ksiazaczak λh model. For the solubility data of three binary solvent mixtures, the modified Apelblat model, the combined nearly ideal binary solvent/Redlich−Kister (CNIBS/R−K) model, and the Jouyban−Acree model were used to fit. In all four models, the modified Apelblat model had a better correlation with the solubility of L-prolinamide weather in pure solvents or binary solvent mixtures. The experimental results showed that n-heptane and n-hexane could be used as antisolvents, which could be used in the purification process of L-prolinamide and guide the large-scale production of many drugs such as Alpelisib in industries.

In this paper, the solubility of 2-amino-5-chloro-3-methylbenzoic acid under 0.1 MPa atmospheric pressure and temperature T = 278.15−323.15 K was determined by gravimetric analysis. Considering the safety and the cost of solvents, we selected the following 10 pure solvents and three binary mixed solvents: methanol, ethanol, n-butanol, acetone, acetonitrile, ethyl acetate, n-propanol, isopropanol, xylene, and n-hexane (n-hexane + acetone), (acetonitrile + acetone), and (methanol + acetone). The aim is to find suitable solvent systems for the recrystallization of 2amino-5-chloro-3-methylbenzoic acid. The results indicate that the solubility of 2amino-5-chloro-3-methylbenzoic acid is positively correlated with temperature, and the solubility of 2-amino-5-chloro-3-methylbenzoic acid is better in acetone. The modified Apelblat model, the Buchowski−Ksiazaczak λh model, the Redlich−Kister (CNIBS/R−K) model, and the Jouyban−Acree model were used to fit the solubility data of 2-amino-5-chloro-3-methylbenzoic acid in different solvents, and the experimental values were in good agreement with the calculated values. By comparing the four models, the modified Apelblat model was found to have a good correlation in pure solvents, and the Redlich−Kister (CNIBS/R−K) model was more suitable than the other two models in binary mixed solvents.

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In this study, the data on solid–liquid equilibrium of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]­aniline were studied by the gravimetric method. The solubility of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]­aniline was measured in 10 pure solvents (ethyl acetate, tetrahydrofuran, acetonitrile, dichloromethane, acetone, methanol, acetylacetone, n-propanol, n-butanol, and water) and three binary solvent mixtures (water + tetrahydrofuran, acetone + n-butanol, and ethyl acetate + n-propanol) in the temperature range of 278.15 to 323.15 K under atmospheric pressure. The experimental results show that the solubility of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]­aniline in the abovementioned solvents increases with the increase of temperature. Among the 10 pure solvents, ethyl acetate has the highest solubility. The improved Apelblat model, Buchowski–Ksiazaczak λh model, Redlich–Kister (CNIBS/R-K) model, and Jouyban–Acree model are used for nonlinear fitting of experimental data, and the KAT-LSER model is also used to study the relationship between the solubility of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]­aniline in pure solvents and the interaction between solvent and solute molecules. The physical and chemical information of 4-[2-(N-methylcarbamyl)-4-pyridyloxy]­aniline provided in this report may help its extraction/separation, recrystallization, purification, and formulation development.