No abstract

AbstrakPerspektif akan penuaan dan keadaan tua yang negatif akan memudar bila sejak muda ditanamkan pandangan positif. Penelitian ini bertujuan membandingkan pengetahuan dan mencari korelasi antara pengetahuan dan perspektif mahasiswa Fakultas Kedokteran (FK) dan Teknobiologi (FTb) mengenai penuaan dan keadaan tua. Penelitian ini merupakan studi analitik komparatif dan korelatif dengan metode potong lintang. Penelitian dilakukan di FTb dan FK Unika Atma Jaya periode Januari-Mei 2013. Pengetahuan mengenai penuaan dan keadaan tua diukur dengan Facts about Aging Quiz 1 (FAQ 1). Perspektif terhadap penuaan dan kondisi tua diukur dengan Anxiety about Aging Scale (AAS) dan Aging Semantic Differential (ASD). Sampel sebanyak masing-masing 45 mahasiswa FK dan FTb. Data FAQ 1 memperlihatkan pengetahuan mahasiswa FK dan FTb mengenai penuaan dan keadaan tua kurang baik serta tidak ada perbedaan bermakna (p=0,199). Data AAS memperlihatkan kecenderungan responden tidak takut terhadap lansia, tidak khawatir dengan keadaan fisiologisnya, kurang memperhatikan penampilan fisik, dan tidak takut kehilangan. Data ASD menunjukkan kecenderungan responden merasa lansia akan lebih berguna, tidak bergantung pada orang lain, dan mampu menerima diri sendiri. Uji korelasi FAQ 1 dengan AAS dan ASD tidak menunjukkan hubungan sehingga dapat disimpulkan tidak ada hubungan pengetahuan dengan perspektif terhadap penuaan dan keadaan tua. [MKB. 2014;46(4):209-15] Kata kunci: Keadaan tua, mahasiswa, penuaan Students' Knowledge and Perspectives on Aging and Aged Condition AbstractThe negative perspectives on aged and aging will be diminished if positive perspectives on aged condition and aging have been introduced in young age. This study aimed to compare and test the relationship between knowledge and perspective toward aged condition and aging among medical and biotechnology students. This study was a comparative analytical and correlative study with a cross-sectional method in the period of January to May 2013 conducted at the School of Biotechnology and the School of Medicine Atma Jaya Catholic University of Indonesia. Knowledge towards aged condition and aging was measured using the Facts about Aging Quiz 1 (FAQ 1). Perspective towards aged condition and aging was measured using the Anxiety about Aging Scale (AAS) and the Aging Semantic Differential (ASD). There were 45 students from each school.. Knowledge about aged condition and aging of the medical and biotechnology students was quite low. There were no significant differences (p=0.199) between the two groups. The AAS data showed that respondents did not have any fear of old people.They were also not really concern about physiological and physical appearances and were not afraid of lost. The ASD data showed that they tended to have positive views: the elderly people are useful, independent, and able to accept their condition. The correlation tests between FAQ 1-AAS and FAQ 1-ASD showed no correlation. In conclusion, there is no relationship between knowledge and perspective towards aged c...

The prevalence of cardiovascular diseases in women increases sharply after menopause. In postmenopausal women, thromboxane production increases while prostacyclin decreases. Low dose aspirin reduces the production of both thromboxane and prostacyclin. The present study was an open-label clinical trial with two parallel groups of 15 premenopausal women and 15 postmenopausal women. Twenty-four hours urine was collected from each subject before and after aspirin 100 mg daily for 7 days. The concentration of thromboxane and prostacyclin was measured as their metabolites (11-dehydro-thromboxane B(2) and 2,3-dinor-6-keto-prostaglandin-F(1α)) in urine using enzyme immunoassay methods. This study showed that aspirin significantly reduced thromboxane in both groups with significantly larger percentage reduction in postmenopausal women compared to premenopausal women (73.32 vs. 61.13%, p = 0.021). This study also showed that aspirin reduced prostacyclin significantly in both groups, but the percentage reduction between the groups was not significantly different. The decrease in the ratio of 11-dTXB(2)/2,3-dinor-6-keto-PGF(1α) should be compared to assess aspirin efficacy as an antithrombotic. Calculation of the ratio of 11-dTXB(2)/2,3-dinor-6-keto-PGF(1α) before aspirin consumption was higher in postmenopausal women than in premenopausal women. The decrease in 11-dTXB(2)/2,3-dinor-6-keto-PGF(1α) ratio by aspirin was greater in postmenopausal women than in premenopausal women (1.91 vs. 0.17; p = 0.022). It was concluded that aspirin reduced thromboxane and prostacyclin significantly in each group with significant 11-dTXB(2) percentage reduction between groups and non-significant 2,3-dinor-6-keto-PGF(1α) percentage reduction between groups, but reduced the 11-dTXB(2)/2,3-dinor-6-keto-PGF(1α) ratio much larger in postmenopausal women compared to that in premenopausal women.

Pendahuluan: Olahraga futsal termasuk ke dalam 10 olahraga yang paling sering menyebabkan cedera, dengan tingkat insidensi mencapai 55,2 cedera per 10000 jam partisipasi olahraga. Cedera pergelangan kaki atau ankle merupakan cedera yang paling banyak terjadi. Cedera ankle yang tidak ditangani dengan baik bisa berakibat pada chronic ankle instability. Tujuan dari penelitian ini adalah mengetahui hubungan edukasi kesehatan tentang cedera ankle dan terapi latihannya terhadap tingkat pengetahuan anggota futsal FKIK UAJ. Metode: Penelitian ini merupakan penelitian pre-experimental dengan pendekatan cross-sectional, yang dilakukan di Fakultas Kedokteran Dan Ilmu Kesehatan Unika Atma Jaya dengan purposive sampling. Edukasi kesehatan diberikan dengan menggunakan alat bantu slideshow dan tingkat pengetahuan diukur dengan menggunakan kuesioner. Data dianalisis dengan uji t-test berpasangan. Hasil: Total responden adalah 36 mahasiswa. Tingkat pengetahuan mahasiswa sebelum diberikan edukasi kesehatan tentang cedera ankle dan terapi latihannya memiliki nilai rata-rata 66,3 s.d.11,6 (kisaran 40,0 - 93,3) yang meningkat bermakna menjadi rata-rata 78,5 s.d. 6,3 (kisaran 63,3 - 96,7) setelah diberikan edukasi kesehatan tentang cedera ankle dan terapi latihannya (p <0.05, uji t-test berpasangan)Simpulan: Terdapat peningkatan pengetahuan anggota Medsoccer setelah pemberian edukasi kesehatan tentang cedera ankle dan terapi latihannya. Untuk itu sebelum memulai suatu olahraga, perlu diberikan pembekalan terkait cedera yang mungkin terjadi.

Background: The demand for novel, useful, potential, and safe antifungal drugs and rapid fungal susceptibility test methods due to antifungal resistance and high prevalence of Candida albicans infection are continuing. Therefore, this study aimed to assess and compare the antifungal activity of lactoferrin, apolactoferrin, and oligosaccharides isolated from human, bovine, goat, and formula milk against C. albicans on Mueller-Hinton agar supplemented with 2% glucose and 5 µg/mL methylene blue and sabouraud dextrose agar.Methods: Lactoferrin, apolactoferrin, and oligosaccharides were extracted from human, bovine, goat, and formula milk. Lactoferrin was identified using the Bradford test and Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis. Oligosaccharides were identified using Thin-Layer Chromatography. The antifungal activity of lactoferrin, apolactoferrin, and oligosaccharides against fluconazole-resistant Candida albicans ATCC 10231 was determined and compared using the disk diffusion method on Mueller-Hinton agar and sabouraud dextrose agar. The inhibition zone formed around the disk was observed after 24 hours of incubation.Results: Lactoferrin showed an inhibition zone on sabouraud dextrose agar against C. albicans, but not on Mueller-Hinton agar. Meanwhile, apolactoferrin and oligosaccharides showed no antifungal activity on both agar media.Conclusions: Different agar media in the diffusion disk test can give different results even though using the same test method and substance. These results could shed light and become the useful references on why some potential antifungals could yield a different results in in-vitro studies, in-vivo studies, or clinical trials.