Introduction: Consumption of antioxidant-rich foods and polyphenol treatment can enhance cognitive performance in elderly subjects. Hence, this study was aimed at investigating the effects of aqueous extract of Moringa oleifera leaves on the hippocampus of aluminium chloride-induced alzheimer's disease in adult wistar rats. Method: Twenty (20) healthy adult male wistar rats (Rattus norvegicus), weighing 180-240g were divided into five (5) groups of four (4) animals each. Group one served as normal control group and was given free access to normal saline for 21days, group 2 was given 400 mg/kg of Moringa extract only for 21 days, group 3 was given 200 mg/kg of AlCl 3 for 21days. Group 4 which served as treatment group was given co-treatment of Moringa extract and AlCl 3 for 21 days while groups 5 which served as standard drug group received co-treatment of Simvastatin and AlCl3 for 21 days. Parameters studied include; hippocampal CA3 histopathology, and CA3 histochemical changes after H&E and Congo red stains. Results: This study revealed that aqueous leaves extract of Moringa oleifera and standard drug-Simvastatin-at both Histopathological and histochemical parameter was effective. Moringa aqueous extracts ameliorated the reported histochemical and histopathological effects of AlCl 3 in treated rats. Conclusion: This study reveals that the tested extracts provided efficiently a neuroprotective effect against Alzheimer's disease. The Moringa extract group and Simvastatin group showed effectiveness in treatment of neurodegenerative disease. This shows that Moringa extract is an alternative remedy to Simvastatin in the treatment of neurodegenerative disease.