Biomimetic cell-membrane-camouflaged nanoparticles with desirable features have been widely used for various biomedical applications. However, the current research focuses on single cell membrane coating and using multiple cell membranes for nanoparticle functionalization is still challenging. In this work, platelet (PLT) and leukocyte (WBC) membranes are fused, PLT-WBC hybrid membranes are coated onto magnetic beads, and then their surface is modified with specific antibodies. The resulting PLT-WBC hybrid membrane-coated immunomagnetic beads (HM-IMBs) inherit enhanced cancer cell binding ability from PLTs and reduce homologous WBC interaction from WBCs, and are further used for highly efficient and highly specific isolation of circulating tumor cells (CTCs). By using spiked blood samples, it is found that, compared with commercial IMBs, the cell separation efficiency of HM-IMBs is improved to 91.77% from 66.68% and the cell purity is improved to 96.98% from 66.53%. Furthermore, by using the HM-IMBs, highly pure CTCs are successfully identified in 19 out of 20 clinical blood samples collected from breast cancer patients. Finally, the robustness of HM-IMBs is verified in downstream CTC analysis such as the detection of PIK3CA gene mutations. It is anticipated that this novel hybrid membrane coating strategy will open new possibilities for overcoming the limitations of current theranostic platforms.

In order to achieve reliable quantum-information processing results, we need to protect quantum gates along with the qubits from decoherence. Here we demonstrate experimentally on a nitrogen-vacancy system that by using a continuous-wave dynamical decoupling method, we might not only prolong the coherence time by about 20 times but also protect the quantum gates for the duration of the controlling time. This protocol shares the merits of retaining the superiority of prolonging the coherence time and at the same time easily combining with quantum logic tasks. This method can be useful in tasks where the duration of quantum controlling exceeds far beyond the dephasing time.

Under resonant conditions, a long sequence of landau-zener transitions can lead to Rabi oscillations. Using a nitrogen-vacancy (NV) center spin in diamond, we investigated the interference between more than 100 Landau-Zener processes. We observed the new type of Rabi oscillations of the electron spin resulting from the interference between successive Landau-Zener processes in various regimes, including both slow and fast passages. The combination of the control techniques and the favorable coherent properties of NV centers provides an excellent experimental platform to study a variety of quantum dynamical phenomena. The phenomenon of Rabi oscillations, first studied in 1937 [1], occurs in almost any quantum system under the influence of resonant external driving and is at the heart of various spectroscopic techniques. Landau-Zener (LZ) transitions, first studied in 1932 [2][3][4][5], are intriguing phenomena that are ubiquitous in quantum systems, typically occurring when two energy levels of a quantum system undergo an avoided crossing.Under suitable conditions LZ transitions can be treated as quantum coherent processes, and multiple such processes can interfere constructively or destructively [4]. Depending on the details of the interference, a long and regular sequence of LZ processes can exhibit resonance behavior similar to that seen in Rabi oscillations under weak driving conditions.The oscillations obtained in the case of constructive interference can therefore be seen as a manifestation of Rabi oscillations in the regime of ultrastrong driving [6]. Moreover, the interference between LZ processes gives rise to a number of novel features distinct from the case of weak driving. Particularly interesting is the fact that the patterns of the resonance lines vary drastically depending on whether each passage through the avoided crossing is slow or fast [6].The experimental observation of Rabi oscillations in the LZ regime requires stringent conditions. The coherence time of the quantum system is required to be long enough to allow the coherent interference between multiple LZ processes, and the control fields are required to be accurate and stable in order to precisely adjust the quantum phases that govern the interference effects. In addition, the time resolution of the measurement needs to be high enough to allow the monitoring of the dynamics on short timescales.With the recent advances in various quantum systems [7,8], a number of experiments were able to demonstrate the controlled interference of LZ transitions. Interference between two LZ transitions has been observed in gaseous molecules [9], semiconductor-based quantum dots [10], NV centers [11], and atoms in optical lattices [12]. Evidence for various interference effects involving multiple LZ transitions has been observed in the steady-state behavior of continuously driven superconducting qubits [13,14] and NV centers [15]. However, although those steady-state behaviors have been reported, the experimental observation of the abundant time-domain evolu...