Background and purpose: Quickly screening of high-risk of peptic ulcer (PU) is of great significance to avoid gastrointestinal bleeding after antiplatelet therapy. In this study, we hoped to find a fast and less invasive method for PU screening. Methods: The clinical data of health examined population who were admitted for taking gastroscopic assessment in our hospital, from January 2019 to June 2020, was prospectively collected. PU was defined as a gastric or duodenal mucosal defect >5mm in diameter on gastroscopic assessment. Results: A total of 902 blood samples were enrolled into analysis. Blood indices showed that PGI and albumin (ALB) were both independently associated with PU (all P<0.05). Based on this, we proposed a PGI and ALB Composite Score (PACS), ranged from 0-2. The ROC analysis showed that PACS had a good diagnostic ability for PU (AUC=0.774, P<0.001). The probability of PU was significantly elevated with the increase of PACS score (PACS 0 vs 1 vs 2=7.9% vs 28.6% vs 62.2%, P<0.001). Conclusion: Both serum PGI and ALB were associated with the increased rate of PU in health examined population, and the PACS score based on these two items may be used to identify the population with high risk of PU.

Microalgae-based wastewater management has the potential to serve dual purposes, including biofuel production and wastewater bioremediation. The current study investigates the role of 5-aminolevulinic acid (5-ALA) in the regulation of photosynthesis, biomass accumulation, lipid production, and nutrient removal from wastewater by Chlorella pyrenoidosa. In wastewaters, a 3 μM concentration of 5-ALA was considered optimal, as it increased the photosynthetic light reaction and CO2 assimilation of C. pyrenoidosa cells, thereby facilitating cellular growth, metabolism, and biomass accumulation. The acceleration of algal cellular metabolism increased the substrate pool and enhanced the expression of lipogenic genes, thereby promoting lipid production. Meanwhile, the removal of nutrients from wastewater was accelerated after the addition of 5-ALA. The accelerated nutrient removal from wastewaters following 5-ALA treatment was related to C. pyrenoidosa cell growth. C. pyrenoidosa is capable of utilizing nitrogen and phosphorus from wastewater and accumulating biomass. The biomass from microalgae can be used as a feedstock to produce biofuels. Therefore, the current study provided a novel strategy for simultaneously promoting CO2 assimilation, biomass accumulation, lipid production, and wastewater nutrient removal with microalgae. It is possible to use microalgae for the management of wastewater if research and development on commercializing technologies based on microalgae, both upstream and downstream, are carried out continuously.