No abstract

No abstract

Peripheral nerve injury is a common clinical issue induced by trauma, tumor, and damage caused by treatment. Such factors create chemical and inflammatory alterations at the injury site, which increase nerve deterioration. Thus, minimizing these modifications can lead to nerve protection after injury. The present study sought to evaluate the possible improvement in nerve regeneration and enhancement of functional outcomes by cinnamaldehyde (Cin) administration following sciatic nerve crush in a rat model. Rats (n = 48) were distributed into 6 groups, including sham, injury, DMSO (vehicle group), and Cin groups (10, 30, and 90 mg/kg/day). Using small hemostatic forceps, crush injury was induced in the left sciatic nerve. Thereafter, Cin was administered for 28 successive days. Weekly records were taken for sciatic functional index (SFI) measurements. Further assessments including electrophysiological and histomorphometric evaluations, gastrocnemius muscle wet weight measurements, and estimation of the serum total oxidant status were performed. According to the results, Cin could accelerate sciatic nerve recovery after crush injury, and the dose of 30 mg/kg/day of Cin had better impacts on SFI recovery, muscle mass ratio, and myelin content. The current research demonstrated that Cin positively affects peripheral nerve restoration. Therefore, Cin therapy could be considered as a potential treatment method for peripheral nerve regeneration and its functional recovery. However, more investigations are required to further validate the study results and evaluate the optimal dose of Cin.

Background and Objectives: Surgery is always a great experience for the patient because surgery of any kind is a threat to the integrity of the body and life. This study was to evaluate the factors of anxiety and stress before surgery in patients who are candidates for spine surgery. Methods: The present study is a descriptive study that was performed on 120 patients who were candidates for spine surgery in of Peymaniyeh Hospital in Jahrom City 2021. Data collection tools were theoretical questionnaire and colleagues. Data were analyzed using SPSS v.22 and descriptive statistics such as frequency, percentage and Pearson correlation coefficient. Results: The results showed that the highest level of anxiety was related to the area of preoperative anxiety (85.1)and in this area, the components of fear of surgery and not knowing the time of surgery (93.3%)and in the area of stressors in relation to Operating room staff for preoperative care also included the components of the patient being left alone until the start of surgery and the observation and encounter of strangers such as anesthesiologists and operating room nurses, causing the most anxiety (88.3%)in patients. Conclusion: Based on the findings of this study, by identifying the factors affecting preoperative anxiety and eliminating them, the amount of preoperative anxiety can be minimized. Therefore, it is suggested to use various methods to educate patients to eliminate the factors affecting anxiety.