This study has examined the response of two species of the blueberry bushes: Elliot and Bluecrop cultivated in the climate conditions of the years 2014 and 2015 to the attack of the Phomopsis vaccinii; we have also testedand determined the biological efficiency of three fungicide products in order to recommend the best of them to be used in the bushes treatment. The attack was calculated by determining the disease frequency (F%) and its intensity (I%). We also calculated the biological efficiency for the three selected products, considered as being the best ones. We utilized the interrupted-linear setting method which consists of 5 plants/three repetitions / product and we monitored 3 plants from each repetition; 2 marginal plants were for untreated control. Our analysis of the two species pointed that the Bluecrop species has a much higher sensitivity against the pathogen than the one discovered in the Elliot species. The calculation of the biological efficiency proved that the best product Funguran OH 50 PW (90,5%) was followed by Alcupral 50 PU (88,8%) and the Copac ( 86,2%) for the Elliot variety, occupied the last place; the same hierarchy with smaller values was found for the Bluecrop variety.