Bolesti srca i krvnih žila glavni su uzrok smrti u Hrvatskoj. Jedan od čimbenika rizika za nastanak kardiovaskularnih bolesti je abdominalna pretilost. U novije vrijeme kao pouzdanija metoda za utvrđivanje te pretilosti primjenjuje se omjer opsega struka i visine, tzv. WHtR kriterij. Prema dosadašnjim istraživanjima problem debljine počinje već od pete godine života. Radovi koji su obuhvaćali i ovu dobnu skupinu primijenili su vrijednosti WHtR ≥ 0,5 kao povišenu za sve dobne skupine i oba spola. No najnovija istraživanja ogra

For several decades, metformin has been the mainstay of treatment of type 2 diabetes (T2D), not only due to its remarkable efficacy in both monotherapy and combination therapy regimens, but also due to its favorable safety profile, weight neutrality, and low cost. Other advantages have been reported, including improvements in lipid profile and inflammatory markers and reports of cardioprotective effects, albeit with scant evidence. The modification of the cellular energy metabolism is the core of metformin’s mode of action. Metformin works to lower serum glucose concentration by inhibiting hepatic gluconeogenesis and countering the action of glucagon. Secondarily, it enhances glucose uptake in peripheral tissues, predominantly in the muscles. Long-term and widespread use of metformin has shed light on its other potential uses mediated by its effects on deranged metabolic pathways. Moreover, metformin is gaining research interest by demonstrating its potential in the treatment of multiple disorders other than diabetes and has been proven to have anti-cancer, immunoregulatory, and anti-aging properties. As a result, metformin is currently being researched as a potential treatment option for various diseases.

This case report details the clinical picture of a renal transplant recipient infected with community acquired Legionella pneumonia. While it is more commonly associated as a nosocomial infection due to pathogenic organisms in a hospital’s water supply, this case serves as a reminder to consider the patient’s impaired cellular immune function when trying to diagnose community acquired pneumonia.

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