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Clin Invest Med 2008; 31 (3): E138-E149. AbstractPurpose: To examines the hypothesis that smoking exacerbates health problems in young male smokers (age range, 18.6-22.8 yr; mean, 19.4 yr). Methods: 1169 subjects were recruited, 25.41 % were smokers (2-15 cigarettes daily). All subjects were examined for body mass index, blood pressure, exhaled carbon monoxide content (carboxyl hemoglobin), blood hematology and biochemistry. Results: Data for WBC (P<0.001), hemoglobin (P=0.001), hematocrit (P=0.004), MCV (P=0.001), MCH (P=0.003), COHB% (P<0.001), albumin/globulin (P<0.001) and triglyceride (P<0.001) were higher for smokers than nonsmokers, while total-bilirubin (P<0.001), total protein (P<0.001) and globulin (P<0.001) were markedly lower. Conclusion:The findings emphasize the importance of increasing surveillance of diseases exacerbated by smoking and reducing smoking in the young to prevent cardiovascular illnesses, metabolite disorders and other clinical diseases.