The satisfaction of employees with organizational climate is predictor of better performance. Organizational climate is having direct bearing on employees' satisfaction. The satisfaction of employees with organizational climate enhances positive organizational outcomes: efficiency, productivity, organizational commitment and cohesiveness of coworkers while it reduces negative outcomes: turnover, deviant behavior at work, absenteeism and stealing of company property. This study is conducted to measure the satisfaction of middle managers with organizational climate in pharmaceutical sector of Pakistan. A questionnaire survey was conducted to collect the response. 66 organizations were selected through cluster sampling technique, from four major cities of Pakistan, out of the total 66 companies (51 local and 15 multinational organizations). Out of these organizations 246 middle level managers were surveyed (170 from local companies and 70 from multinationals). The majority of them were male, having university degrees, with age less than or equal to 35 years. The results reveal that in majority of the managers were satisfied with organizational climate in both local and multinational organizations. Respondents from multinational organizations were found to be more satisfied then the respondents from local companies. Detailed results are discussed in findings section.