Background A new clinical syndrome has been recognized following the COVID-19 vaccine, termed thrombosis with thrombocytopenia syndrome (TTS). The following systematic review focuses on extrapolating thrombotic risk factors, clinical manifestations, and outcomes of patients diagnosed with TTS following the COVID-19 vaccine. Methods We utilized the World Health Organization's criteria for a confirmed and probable case of TTS following COVID-19 vaccination and conducted a systematic review and posthoc analysis using the PRISMA 2020 statement. Data analysis was conducted using SPSS V25 for factors associated with mortality, including age, gender, anti-PF4/heparin antibodies, platelet nadir, D-dimer peak, time to event diagnosis, arterial or venous thrombi. Results Of the 175 studies identified, a total of 25 studies with 69 patients were included in this systematic review and post hoc analysis. Platelet nadir ( P < .001), arterial or venous thrombi ( χ2 = 41.911, P = .05), and chronic medical conditions ( χ2 = 25.507, P = .041) were statistically associated with death. The ROC curve analysis yielded D-dimer (AUC = .646) and platelet nadir (AUC = .604) as excellent models for death prediction. Conclusion Adenoviral COVID-19 vaccines have been shown to trigger TTS, however, reports of patients having received mRNA COVID-19 vaccines are also present. Healthcare providers are recommended to maintain a high degree of suspicion among individuals who have received the COVID-19 vaccine within the last 4 weeks.

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Gill, W. A., Khan, M. U., Shafiq, Z., Janjua, M. R. S. A., “Exploring the Intermolecular Interactions in Carbon Disulfide Dimer: An Ab Initio Study Using an Improved Lennard–Jones Potential Energy Surface for Physical Insights,” J Phys Org Chem 2023, https://doi.org/10.1002/poc.4548. The above article, published online on 05 June 2023 on Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editor in Chief, Professor Rik Tykwinski and John Wiley and Sons LLC. The journal's Editor‐in‐Chief was contacted by a third party who raised concerns about the article. An independent scientific expert evaluated the article and confirmed that significant problems exist with the data and conclusions of the work, and that it contains inadequate and/or inaccurate citations. As a result, the editors consider the article's conclusions to be unreliable.

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