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Objective: Verification and application of the theory of brain cell activation. Methods: Applying transcranial magnetoelectric encephalopathy treatment instrument to the treatment of neurodegenerative disease, including but not limited to: Parkinson's disease and Alzheimer's disease. Results: Transcranial magnetoelectric encephalopathy treatment instrument, its double-center, randomized, double-blind clinical trial has been carried out at the national clinical trial base, it proves that the instrument is safe and effective. This instrument is especially suitable for the treatment of the following diseases: (1) it is suitable for the treatment of mild to moderate Parkinson's disease and can significantly improve resting tremor, rigidity, bradykinesia in patients with Parkinson's disease and other symptoms; (2) it is suitable for the treatment of mild and moderate Alzheimer's disease and vascular dementia and can improve the mental state, cognitive behavior and self-care ability of daily life; (3) it is suitable for the treatment of mild to moderate depression and can obviously improve the main symptoms of depression, sleep disorder, anxiety and so on; (4) it is suitable for the treatment of cerebral apoplexy sequelae, cerebrovascular dementia and brain atrophy, and it can activate the brain cells in the state of inhibition and mobilize the potential energy of the brain. Conclusions: The theory of brain cell activation is applicable to encephalopathy and not limited to encephalopathy, according to this theory, the subject of "physical disease science" can be created.

This is a new idea that based on effective treatment of Parkinson's disease and Alzheimer's disease with transcranial magnetoelectric stimulation technology. It is a hypothesis that Voltage gated Ca 2+ channels can activate the best target by Physical means. Basic content: neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, are closely related to voltage-gated calcium channels. The key method of treatment is activation of neurotransmitter neurons. Voltage gated Ca 2+ channels are the best target for activation by physical means. The aim is to induce calcium influx to trigger synaptic vesicles released from axon terminals and release neurotransmitters. The theory of brain cell activation sets forth the principle, method and purpose of treatment of the physical gated ion channel diseases such as Alzheimer's disease, Parkinson's disease and other neural degeneration diseases, and indicates that the attempt to treat these diseases using pharmaceutical and chemical approaches could shake our confidence in conquering the diseases, and the application of physical approaches or combined application of physical and chemical approaches in the treatment of some major encephalopathy may be our main research direction in the future.

Objective: Alzheimer's disease (AD) has been reported for more than 100 years since its first discovery in 1906. There has been no significant progress in the study of its real causes and pathogenesis. The viewpoint of this paper is a heuristic viewpoint based on brain cell activation theory under such background. In this paper, the pathogenesis of sporadic AD is discussed at molecular level by applying the principles of cell physics and biology. The purpose of this paper is to harmonize the existing theories of etiology of AD and to solve the source problems that have plagued the research field of neurodegenerative diseases for a long time. Method: (1) Discuss the relationship with the existing hypothesis: the Aβ protein hypothesis, the tau protein hypothesis, the presenilin (PS) hypothesis, the apolipoprotein E (ApoE) hypothesis, the cholinergic hypothesis, the inflammatory hypothesis; (2) Demonstration: biophysical proof, medical pathological proof, biological model proof; (3) Interpretation: ion channel and blood-brain barrier, potassium ion and potassium channel, ion pump and epilepsy and cancer, A beta protein and spots and plaques, related AD solutions. Result: (1) Abeta is not the cause of AD, but the remains of brain cells after abnormal apoptosis; (2) The K + concentration difference of 0.00001% which causes the great change of membrane potential is the effective concentration, which can not be neglected; (3) Abnormal impairment of potassium channels and early entry of sodium ions to occupy potassium positions are related to epilepsy, cancer and HeLa cells; (4) AD is a physical disease, especially transcranial magnetoelectricity stimulation, should be the first choice for treatment, which can activate abnormal neurons accurately without interfering with normal neurons. Conclusion: (1) Basic contents: excess cations are transferred from extracellular to intracellular. They compete position with potassium ions on the inner surface of cell membranes, thus abatementing the membrane potential, making action potential unable to activate calcium channels normally, which eventually leads to abnormal apoptosis of brain cells. Amyloid plaque is the remains of abnormal apoptotic brain cells. Amyloid plaque is the aggregation of amyloid spots by van der Waals force and electrostatic attraction, and its interstitium is amyloid protein. Brain cells consist of neurons, microglia and astrocytes in turn. Most of the spotted nuclei in the remains are cations. (2) Solutions: the core viewpoint of this paper can be regarded as exploring the etiology of sporadic AD, it is companion volume of Brain cell activation theory, brain cell activation theory is an explanation of the treatment methods and mechanism of neurodegenerative diseases such as AD, it is suitable for encephalopathy but not limited to encephalopathy, the solution of AD should start with prevention and treatment, the external factor of prevention is environment, especially heavy metal ions, the internal cause is body acidity and alkalinity, physical means, espe...