We investigated the luminescence properties of protein-directed Au∼20 clusters upon hard X-ray irradiation, demonstrating the further possible application toward nanomaterial based bio-imaging and diagnostics.

The development of efficient antibacterial agents is important for public health. To completely damage bacteria in situ, light has been used as an external stimulus, but the wavelength range of light is limited up to visible light at which the antimicrobial activity is incomplete. Here, we report on our investigation of the bactericidal effect of heat and nitric oxide (NO) generated simultaneously by near-infrared (NIR) light using vanadyl naphthalocyanine-doped polymer dots (Pdots). P-dots co-doped with vanadyl naphthalocyanine and N-nitroso compounds generated heat and released NO upon NIR light irradiation. The amount of NO released was dramatically enhanced owing to the ease of bond dissociation in Nnitroso compounds in the presence of generated heat. The anti-bacterial effect of Pdots on Staphylococcus epidermidis and Pseudomonas aeruginosa was clearly caused by heat and NO, demonstrating the potential use of P-dots as antimicrobial agents.

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We demonstrate that polymer dots doped with thermally activated delayed fluorescence (TADF) molecules clearly exhibit blue radio-luminescence upon hard X-ray and electron beam irradiation, which is a new design for...

Nitric oxide (NO) is a signaling molecule that has a variety of functions in the human body, but is difficult to apply in biological experiments or for therapeutic purposes because...