Introduction: A new way of converting light radiation is based on the assumption that it is possible for fullerene C 60 molecules to influence it. Physical calculations indicate that in this case there are prerequisites for changing the configuration of the quantum-wave structure of the light flux (hyperharmonization). Our previous studies revealed a possibility of obtaining biological responses to the light reorganized by fullerene. We investigated the effect of application of hyperharmonized light through the organ of vision on the neural structures of the brain associated with it. Transformation of the light was created by using glasses with fullerene filters (THE ® -glasses). The purpose of this work was to establish whether the light that passed through the fullerene-containing filters installed in glasses affects mental performance of a person; in particular, the speed and quality of performing visual-motor tasks similar to those performed by a person using a computer. Methods: We selected eighteen clinically healthy volunteer participants of both sexes aged from 10 to 78 years with computer skills. In the study we used specially made glasses, the filters of which contained 0.33‰ of fullerene in polymethylmethacrylate (Tesla Hyperlight Eyewear ® ; THE ® -glasses), as well as glasses with darkened filters and a frame of similar design (placebo). The spectrum of light that came into the eyes of the participant was natural (intact light, control) or with a weakened blue spectrum, the wave range of which started from ~420 nm (fullerene light, placebo light). The participants' mental performance was assessed according to the results of specially designed tests: black-white and color tests of digital sorting and the correction test (simple and of increased complexity). Testing was conducted in 3 series: without glasses in natural light (intact light), in glasses with fullerene-containing filters (fullerene light) and in glasses of similar light transmission, but without fullerene (placebo light). The quality control of tests and the calculation of psycho-physiological indicators were performed automatically using the processing program built into the test. The obtained data were processed statistically. Results: It was established that under the action of light passing through filters containing fullerene installed in the glasses, the execution time of the visual-motor task was reduced by 16.5% (for the black-white digital sorting test), and the number of errors by 2.7 times (in color digital sorting test) compared to testing with intact lighting. Apparently, the fullerene light positively influenced the speed of information processing and attentiveness. A simple correction test with presentation of 2,000 characters showed that when being in THE ® -glasses (fullerene light), the fatigue significantly decreased compared to testing with intact light or placebo light. The concentration ratio in fatigue conditions (end of testing) decreased by 16.2% (fullerene light), by 28.5% (placebo light) and by 23.6% (intact lig...

INTRODUCTION: Our previous studies have shown that exposure of acupuncture points (AP) or painful area of mice to halogen polarized light (PL) effectively weakens the pain. The aim of the study was to determine whether exposure of AP or painful area to LED red-infrared PL evokes analgesic effect. METHODS: The duration of licking the formalin-injected foot (tonic pain) was recorded in control group and mice exposed (5 min, 10 min) to red+infrared LED light on AP E-36 or on the painful area. Power density of the light varied from 0.3 to 16.5 mW/cm 2 . RESULTS: Exposure of AP E-36 or painful area to red-infrared LED PL evoked statistically significant decrease of licking time. The effect depended on the light application duration and its power density. 10-minute light exposition was more effective than 5-minute. The exposure of pain source to LED PL shortened the licking time to 44.1% (at 16.5 mW/cm 2 ) and to 64.4% (at 0.3 mW/cm 2 ). CONCLUSION: The results show the efficacy of pain suppression by exposure of antinociceptive AP or painful area to LED red+infrared PL. The effect depends on the duration of light exposure and its power density.

Part of the unidirectional light waves (background polarization) due to the passage through the layer of fullerene molecules, acquires the properties of an ordered concentrated nano-photonic flow, called hyperpolarized. The aim was to investigate the effect of prolonged illumination of an animal with natural daylight passing through a fullerene filter, on behavior, physiological health indices and life expectancy. A long 8-month experiment was conducted on 12 male mice at the age of 1 year. Half of them were constantly under "fullerene" light (experimental group), the rest-under natural light (control). The spectrum of light passing through the fullerene filter was characterized by a weakened short-wavelength range and power density. Weekly we determined the body weight, recorded motor activity (open field test), dynamics of natural behavioral reactions (sleeping, eating, running, washing). It was found that after 9 weeks of observation the body weight in the control group animals began to decrease gradually (one of the signs of aging). At the same time, the average body weight in the animals of the experimental group remained at the same level or even increased. The maximum difference between the two groups occurred 32 weeks after the start of the experiment. The body weight of animals receiving fullerene light was 38.25 g (20.5% increase) in this period, while in the control group it fell down to 27.42 g (a decrease of 13.8%). The test "open field" showed that as the natural aging of animals continues their motor activity decreases. However, in the control group, this process is faster than in animals under the "fullerene" light. After 8 weeks of observation, the mobility of animals in the experimental group was significantly higher than in the control group. It is proved that the "fullerene" light preserves the natural behavior of animals (sleeping, eating behavior, etc.). The animals of the experimental group lived for a total of 1,032 days, and the control animals-1,036 days. Nevertheless, the quality of life of the "fullerene" animals was the best. This was evidenced by better dynamics of body weight, greater motor activity, and absence of negative behavioral changes. Thus, it was shown for the first time that for a long time up to 8 months illumination of the animal's body with light transmitted through a Nano photonic fullerene filter does not adversely affect physical and functional indices and some of them even improve. Development of some signs of aging is slowing down: weight loss and decreased mobility, although there is no reliable difference in life expectancy between experimental and control animals. The obtained results create the prospect of using fullerene filters for improving ergonomics of the dwelling (fullerene window), everyday use (fullerene glasses), medical purposes (light therapy devices with fullerene filters), for plants (fullerene greenhouses), etc.

On the model of formalin test in mice, the analgesic effects of low-intensity polarized light (PL) of BIOPTRON device (480-3,400 nm, polarization up to 95%, power density 40 mW/cm 2) and three pharmacological analgesics (ibuprofen, analgin, tramal) were compared. We used analgesics in the optimal and half-dose, as well as half-doses of analgesics combined with the application of PL to the analgesic acupuncture point (AP) E-36. Pain was induced by subcutaneous injection of a 5% formalin solution (30 μL) into the back of the foot of the left hind limb of the animal. The intensity of pain was judged by duration of pain (licking of the affected limb) and non-painful (sleeping, eating, running, washing) behavioral reactions during 60 minutes of observation. In animals that immediately after the creation of the locus of tonic pain, received an injection (intraperitoneally) of ibuprofen, analgin or tramal in optimal doses (30.0; 8.3 and 1.7 mg/kg), duration of the pain response reduced by 46.0; 74.9 and 56.2%, respectively. Half doses of these analgesics (15.0; 4.2 and 0.8 mg/kg) weakened the pain by 23.1; 28.5 and 34.2%. A statistically significant reduction of pain was also observed in groups where instead of analgesics, was applied a 10-min PL session to the anti-pain AP E-36 (by 27.0%) or to the locus of pain (by 35.8%). These data indicate that PL analgesic effect is comparable to the effect of moderate doses of analgesics. Combined use of analgesic and PL suppresses pain more effectively than one analgesic in the same dose. The 10-minute PL application to the analgesic AP E-36 in 1.5-2 times (statistically significantly) increased the analgesic effect of small analgesics doses. In contrast to animals in which analgesia was caused by administration of high doses of analgesics, in the case of low doses of analgesic in combination with PL, caused no disturbances in motor activity and eating behavior. Clinical significance of the presented data is to prove the possibility of reducing the dose of analgesic pharmaceuticals by applying PL, which reduces the risk of unwanted side post-pharmacological effects.

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