The aim of the present Thesis is to investigate the evolution and the spatial distribution of air pollution in Thriassion Plain during the years 1986-2007, in conjunction to certain climate indices as well as changes in population and activities established in the area, causing land use changes over time. The results can summarize as follow: Established activities in coastal area tend to intensify heat island effect in Thriassion Plain; meteorological indeces identify drying tendencies for Thriassion Plain and there is some improvement in air quality. The statistical analysis indicates correlation between population and established activities, as well as between climate indices and air quality indices. Air quality indices increase (e.g. ambient air quality is stressed) when climate indices suggest dryer climate.