Íà äàííûé ìîìåíò ïðîáëåìà àíòèáèîòèêîðåçèñòåíòíîñòè ÿâëÿåòñÿ îäíîé èç ñàìûõ àêòóàëüíûõ. Ýôôåêòèâíîñòü àíòèáàêòåðèàëüíîé òåðàïèè îïðåäåëÿåòñÿ, â òîì ÷èñëå, è ôàðìàêîêèíåòè÷åñêèìè õàðàêòåðèñòèêàìè àíòèáàêòåðèàëüíîãî ïðåïàðàòà. Òåðàïåâòè÷åñêèé ëåêàðñòâåííûé ìîíèòîðèíã (ÒËÌ) ÿâëÿåòñÿ ñîâðåìåííûì ñïîñîáîì ïðåîäîëåíèÿ óñòîé÷èâîñòè âîçáóäèòåëåé â óñëîâèÿõ ñòàöèîíàðà, êîòîðûé ïîçâîëÿåò èíäèâèäóàëèçèðîâàòü äîçû ïðåïàðàòà, îñîáåííî ó ñëîaeíûõ ïàöèåíòîâ ïðè ïîâûøåííîé ðåçèñòåíòíîñòè âîçáóäèòåëåé.  ñòàòüå îïèñàíû äâà êëèíè÷åñêèõ ñëó÷àÿ íàçíà÷åíèÿ ìåðîïåíåìà è ïðîâåäåíèÿ ÒËÌ, ÷òî ïîçâîëèëî èíäèâèäóàëèçèðîâàòü äîçèðîâêè àíòèáàêòåðèàëüíîãî ïðåïàðàòà è îáåñïå÷èòü àäåêâàòíóþ è ýôôåêòèâíóþ òåðàïèþ ïàöèåíòàì.  îïèñàííûõ êëèíè÷åñêèõ ñëó÷àÿõ ïðåäëîaeåííûé ðåaeèì äîçèðîâàíèÿ ìåðîïåíåìà ïîçâîëèë äîñòè÷ü öåëåâûõ çíà÷åíèé ïîêàçàòåëÿ % T> ÌÏÊ -áîëåå 40%. Êëþ÷åâûå ñëîâà: ìåðîïåíåì, àíòèáàêòåðèàëüíàÿ òåðàïèÿ, òåðàïåâòè÷åñêèé ëåêàðñòâåííûé ìîíèòîðèíã.Antibiotic resistance is one of the most relevant problems nowadays. The effectiveness of antibiotic therapy is determined, among other things, by the pharmacokinetic characteristics of the antibacterial drug. Therapeutic drug monitoring (TDM) is a modern way of overcoming the resistance of pathogens found in hospitals, which allows individualizing doses of the drug, especially in complex cases with increased pathogen resistance. The article describes two clinical cases of prescribing meropenem and conducting TDM, which made it possible to individualize the dosage of the antibacterial drug and provide adequate and effective therapy to patients. In the described clinical cases, the proposed dosing regimen of meropenem allowed achieving the target values of % T> MIC -more than 40%.