Relevance. Currently, the incidence of COVID-19 is growing in many countries of the world, including Russia. There are suggestions about a likely protective role against the new coronavirus infection of widely used traditional vaccines against respiratory infections (influenza, tuberculosis, pneumococcal infection). Those vaccinated with these vaccines are less likely to report deaths and severe forms of COVID-19 diseases in vulnerable populations.The aim is to determine the frequency of detection of positive markers of a new coronavirus infection in individuals with different vaccination histories.Materials and methods. We examined 313 employees of an educational institution with various vaccination histories at the age of 20–54 years from May to September 2020. The determination of SARS-CoV-2 RNA and specific IgM and IgG antibodies to the virus nucleocapsid was carried out.Results. Positive markers for SARS-CoV-2 (PCR and / or ELISA) were found in 51 (16.3%) people. All examined patients had no signs of acute respiratory viral infections. Among people with positive markers of coronavirus infection (PCR and / or ELISA), the number of people vaccinated against diphtheria, tetanus, measles and hepatitis B (HBV) was 13.7–17.6% of those examined. Among those with negative PCR results, the number of people vaccinated against these infections was higher (p ≤ 0.05) and amounted to 51.0–56.6%. Similar results were found in the determination of specific IgM and IgG.Conclusion. Positive markers of a new coronavirus infection were found much less frequently in persons who had a history of vaccination with ADS-M-toxoid, measles and hepatitis B vaccines.

Background. Patients with first diagnosed prostate cancer, kidney cancer and bladder cancer, more than 25% of cases are diagnosed at stage IV disease at the primary visit in clinics. A characteristic feature of these types of tumors is a predisposition to bone metastasis. Bones failure at the treatment stages is diagnosed in 80% of patients already.Objectives. Determine the most effective palliative analgesic radiotherapy regimens.Materials and methods. Case histories of 41 patients with a diagnosis of osteolytic bone lesion were analyzed. The male / female ratio is 32/9. All patients underwent radiotherapy in the Radiological Division of the Rostov District Oncological Dispensary for the period from 2015 to 2018Results. The direct effectiveness of the analgesic effect of large-fraction radiotherapy is slightly higher than that of single-fraction radiotherapy. However, the opposite trend was observed a month after the R-therapy end. It was determined that higher analgesic effect corresponds to higher values of a single focal dose (SFD).Conclusion. This method deserves closer attention despite the low direct efficiency of single-fraction radiation. This is due to the high and persistent analgesic activity and the short duration of the course

Болезнь Боуэна, эритроплазия Кейра и бовеноидный папулёз в настоящее время отнесены к предраковым поражениям полового члена, связанным с вирусом папилломы человека. Диагностика и лечение предраковых поражений полового члена представляет собой уникальную задачу. Редкость этих состояний и низкая заболеваемость раком полового члена означают, что большая часть наших знаний основана на небольших, нерандомизированных ретроспективных исследованиях. В статье описан клинический случай успешного лечения рецидива эритроплазии Кейра с применением близкофокусной рентгенотерапии, представлен обзор наиболее значимых публикаций, посвящённых теме предраковых поражений полового члена. Ключевые слова: половой член; плоскоклеточный рак in situ; эритроплазия Кейра; близкофокусная рентгенотерапия Финансирование. Исследование проведено без спонсорской поддержки. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. Информированное согласие. Пациент подписал информированное согласие на публикацию своих данных.

Prostate cancer (PCa) remains one of the most pressing problems of modern oncology, which is primarily associated with the high prevalence of this pathology. Of course, the appearance of metastases is an unfavourable factor in the course of the disease. However, PCa metastases is a very heterogeneous condition. «Oligometastatic cancer» is considered as a special disease with other properties of the tumour, i.e. as a transitional state between the localized and disseminated stage of the disease. Diagnosis of oligometastatic cancer is an extremely difficult task associated with the accurate determination of the number and localization of metastases, both hematogenous and lymphogenous, which in turn requires differentiation with regional lesions of the lymph nodes of a locally advanced tumour process. Currently, radiotracers are widely used to diagnose metastatic lymph node lesions that have high specificity for PCa, targeting a prostate-specific membrane antigen (PSMA; also known as glutamate carboxypeptidase), such as 11C-choline, 18F-fluoroethylcholine, 68Ga.9 patients with prostate cancer with the oligometastatic lesion were treated. All patients underwent external beam radiation therapy. Total focal dose on the visualized lymph collector of the affected lymph node amounted to 44.0 Gr. Total focal dose with the method of radiotherapy treatment «field in the field» on the node 70.0 Gr. In all patients, a PSA was reduced to a level below 1.0 ng/ml 6 weeks after completion of the course of radiation therapy and levelling the severity of adverse reactions. None of the treated patients showed signs of a PCa recurrence.