The paper dwells upon the use of information and computer technologies in the maintenance and support of career guidance and professional self-determination for students with health disabilities; it determines the forms and methods of their application and peculiar features of the interaction of those involved in the psycho-pedagogical process.The basis for physiological support of children with health disabilities is formed by the following principles, which take into consideration the psycho-pedagogical features of distance learning: (A) priority of the student’s independent work; (B) individual approach to learning; (C) motivating as basic learning environment; (D) connection between the learning process and the student’s life circumstances (“life knowledge”); (E) intensification of the training process (everyone has their own pace and rhythm); (F) polymodality, i. e. simultaneous mobilization of different ways of perception (auditory, visual, tactile); (G) flexibility and innovativeness; (H) emergency psychological help in acute situations of mental and emotional distress, and other structural and substantive changes of learning activities. The same principles are incorporated in the psycho-pedagogical support career guidance.The paper shows that professional orientation of children with health disabilities should be implemented comprehensively, using a variety of information resources of the Internet: websites, educational portals, employment resources and test resources.A wide and varied range of possibilities offered by ICT and distance learning technologies can be of significant assistance not only to specialists in the field of education, but also in such processes as vocational guidance and professional self-determination of children, formation of personal stability for students with learning disability, including permanent one.