Patients with duodenal ulcer after successful eradication have improvement of morphological and functional characteristics of gastric mucosa.

The pattern of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of resistance to clarithromycin H. pylori. During the examination of 125 patients with proved H. Pylori contamination the restriction analysis of 23S rRNA gene fragment of H. Pylori did not detect T2717C point mutation connected with the phenotype of low level of resistance to clarithromycin. The phenotype of high level of resistance to clarithromycin was detected only in 5,5 % of patients. Taking into account low indicators of phenotypic resistance, the conclusion that clarithromycin can be successfully used as a preparation of the first line of eradication therapy of H. Pylori in the Republic of Belarus has been made.

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