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In some regions of Ukraine, the environmental conditions can be considered as threatening for the life of people and animals. There has been reported excessive accumulation of nitrates in the bodies of humans and animals with food and drinking water in regions with developed agriculture. At the same time, in regions with developed chemical and metallurgical (especially aluminium production) industries, additional contamination of drinking water with excess fluoride has been found out to take place. Thus, simultaneous excess intake of nitrates and fluorides into the human body cannot be excluded. The purpose of this work is to determine the effect of nanosized silica, Carboline and hydrolytic lignin suspensions on the production of superoxide anion radical (О2∙-), the activity of antioxidant enzymes, the content of oxidative-modified proteins and the concentration of primary products of lipid peroxidation (POL). Materials and methods. All biochemical studies were carried out in 10% gastric mucosa homogenates of the rats. The study assessed the activity of superoxide dismutase (SOD), catalase, content of diene conjugates, octadiene conjugates, trien conjugates, the content of oxidative-modified proteins (OMP) and О2∙- production. Results. Chronic nitrate-fluoride intoxication leads to an increase in the basic О2∙- production with a simultaneous decrease in the activities of SOD and catalase. The content of primary POL and OMB increases during chronic intoxication. Usage of enterosorbent suspensions reduces О2∙- production, restores functioning of antioxidant enzymes, lowered the content of primary POL and OMP. Conclusions. Chronic nitrate-fluoride intoxication leads to oxidative damage to the phospholipids of biological membranes and the protein structures of the gastric mucosa. Suspensions of nanosized silicon oxide, carboline and lignin are effective means for correcting oxidative damage to the gastric mucosa during chronic nitrate-fluoride intoxication.

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