The review summarizes the results of 30-year clinical application of the prostatic bioregulatory peptide Prostatilen. The data from experimental studies, testifying for the high biological activity of the drug is shown, the mechanisms of its therapeutic action are described. The review presents the results of clinical studies demonstrating the effectiveness and pathogenetic justification of the prescription of Prostatilen in the treatment of chronic prostatitis, benign prostatic hyperplasia, infectious and inflammatory diseases of the kidneys and urinary bladder, as well as of several other diseases. The experience of Prostatilen application in the urological clinic of First Pavlov Saint Petersburg State Medical University is shown.
The investigation of the metabolic activity of leukocytes and the effect of bioregulation peptide of the prostate prostatilen on it is performed. It is found that suppression of oxygendependent microbicide systems of phagocytes, more pronounced in the initial form of the disease, occurs in patients with chronic pyelonephritis. The differences in the activity of oxygenindependent systems of phagocytes in patients with chronic pyelonephritis and healthy persons are not revealed. The increase of NST-test values after the use of prostatilen is noted.
ВВЕДЕНИЕСлизь образуется в результате разрушения форменных элементов крови и является спутни-ком воспалительных болезней. В процессе рабо-ты по созданию модели хронического простатита в эксперименте на мелких лабораторных живот-ных происходит сопутствующее его развитию резкое увеличение размеров семенных пузырьков [1, 2, 3,4, 5]. В настоящем исследовании мы ре-шили уточнить диагностическое значение слизи семенных пузырьков при хроническом простати-те в эксперименте на мелких лабораторных жи-вотных.
мАТЕРИАЛ И мЕТоДы ИССЛЕДоВАНИяИсследование выполнено на 98 беспородных белых крысах-самцах массой 180 ± 30 г в двух се-риях опытов (острый и хронический простатит -46 и 52 крысы соответственно). В каждой серии крысы были разделены на 4 группы.
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