SummaryThe endocannabinoid system can modulate energy homeostasis by regulating feeding behaviour as well as peripheral energy storage and utilization. Importantly, many of its metabolic actions are mediated through the cannabinoid type 1 receptor (CB1R), whose hyperactivation is associated with obesity and impaired metabolic function. Herein, we explored the effects of administering rimonabant, a selective CB1R inverse agonist, upon key metabolic parameters in young (4 month old) and aged (17 month old) adult male C57BL/6 mice. Daily treatment with rimonabant for 14 days transiently reduced food intake in young and aged mice; however, the anorectic response was more profound in aged animals, coinciding with a substantive loss in body fat mass. Notably, reduced insulin sensitivity in aged skeletal muscle and liver concurred with increased CB1R mRNA abundance. Strikingly, rimonabant was shown to improve glucose tolerance and enhance skeletal muscle and liver insulin sensitivity in aged, but not young, adult mice. Moreover, rimonabant‐mediated insulin sensitization in aged adipose tissue coincided with amelioration of low‐grade inflammation and repressed lipogenic gene expression. Collectively, our findings indicate a key role for CB1R in aging‐related insulin resistance and metabolic dysfunction and highlight CB1R blockade as a potential strategy for combating metabolic disorders associated with aging.

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INTRODUCTION. Postoperative pain syndrome remains a serious problem in pediatric surgery and anesthesiology. Epidural analgesia is considered to be effective in the early postoperative period, as it provides better pain control compared with the use of opioids. PURPOSE OF THE WORK. To evaluate the the effectiveness and safety of epidural analgesia after extensive surgical interventions on abdominal organs in children. MATERIALS AND METHODS. The study included 22 children from 1 year to 17 years. They were divided into two groups: 1 group included children who received opioid analgesics parenterally as a postoperative analgesia (n = 10), in group 2 there were patients in whom a prolonged epidural anesthesia was carried out (n = 12). RESULTS AND DISCUSSION. When studying the variability of blood pressure and heart rate during the day, as a marker of pain, it was found that in children of the first group, these fluctuations were much more expressed than in the second group. Peristalsis appeared in 54.61 ± 9.66 hours after surgery in patients of the first group and in 14.22 ± 6.89 hours-in the second group. Diluting the 0.25% solution of anesthetic to a concentration of 0.125% gave an opportunity to increase the rate of solution delivery to cover more dermatomes and expand the analgesia zone. CONCLUSIONS: 1. Prolonged epidural analgesia has advantages over the use of opioids, providing more reliable and effective analgesia in children. 2. Prolonged epidural anesthesia, with the correct technique of catheter placement and strict dosing of local anesthetic, does not have clinically significant side effects in children, and can be recommended for postoperative analgesia after extensive surgical interventions on abdominal organs in children.

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