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The effect of tetraethylammonium in a dose of 1 mM (inhibiting functional activity and preventing opening of BKCa channels) was least pronounced during restraint stress. The influence of this agent was more significant in animals exposed to 14-day hyperglycemia alone or in combination with restraint stress. Therefore, hyperglycemia and stress (individual or combined exposure) significantly inhibit functional activity of BKCa channels in smooth muscles of the coronary vessels. Our results suggest that the development of hyperglycemia is realized via pathogenetic mechanisms of vascular injury in the heart (similarly to stress conditions). Permanent increase in blood glucose level and 6-h immobilization probably induces nonspecific post-stress abnormalities in channel function.

ResultsIn the full population (n ϭ 314), seated trough mean Ϯ SE BP reductions (mmHg) with T80/A5 vs A5 from baseline to Week 8 were -16.2 Ϯ 1.3 vs -11.7 Ϯ 1.3 for SBP (p Ͻ 0.001) and -12.4 Ϯ 0.95 vs -10.2 Ϯ 0.93 for DBP (p ϭ 0.007). T80/A5 provided DBP goal attainment ( Ͻ 140/90 mmHg) in 64.5% vs 45.3% with A5 alone (p ϭ 0.007) and DBP response rate ( Ͻ 90mmHg or Ն 10mmHg reduction) was 80.0% vs 63.5% (p ϭ 0.0017). The incidence of related AEs (including peripheral edema) was 1.9% with T80/A5 and 2.4% with A5. ConclusionsIn Asian patients T80/A5 SPC provided superior BP reductions and goal rate achivement vs A5 monotherapy after 8 weeks of treatment, T80/A5 was well-tolerated and had a safety profi le comparable to A5 monotherapy.Background Urinary albumin excretion (UAE) is a surrogate marker of cardiovascular events in hypertensive patients. Recently, Morning Hypertension and Angiotensin Receptor Blocker/ Hydrochlorothiazide Combination Therapy (MAPPY) study has shown that losartan/ hydrochlorothiazide combination is superior to high-dose losartan

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