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The dynamics of selenium content in the plasma, lymph, and myocardium and plasma antioxidant activity were studied in male NISAG (hereditary stress-induced arterial hypertension) and Wistar rats with acute myocardial infarction and during recovery. In NISAG rats the decrease in selenium content correlated with the decrease in antioxidant activity. This probably aggravates the symptoms of experimental myocardial infarction in animals with hereditary arterial hypertension.

lease in an atherosclerotic plaque as well as formation of autoimmune complexes in situ require further investigations. 2. G. Hansson and S. Stemme, Atherosclerosis X, F. Woodford et al. (eds.), Elsevier Sci. Study of the heart in a new strain of rats with hereditary stress-induced hypertension (NISAG) reveals a complex of structural and functional changes which are analogous to the manifestations of essential hypertension. These changes are shown to be adaptivecompensatory in nature and indicative of limited functional reserves of the hypertrophic myocardium.

Hemolymphatic interactions of electrolytes and plasma contents of aldosterone and insulin are studied in rats with genetically-determined stress-induced arterial hypertension (NISAG) and in normotensive rats (Wistar). Correlation analysis shows that alterations in electrolyte metabolism in NISAG are strongly determined by endocrine influences. These alterations are regarded, on the one hand, as a mechanism responsible for generically-determined arterial hypertension, and, on the other hand, as a variant of "adaptation disease" accompanied by transformation of primarily adaptive reactions into a pathogenic factor of arterial hypertension. Key Words: hypertension; electrolytes; hormones; blood; lymphArterial hypertension (AH) is a polymorphic pathology involving numerous endo-and exogenous factors. The exchange of electrolytes (Na and K) largely determines both vascular tone and fluid homeostasis in the organism [3]. Although lymph vessels play substantial role in the regulation of fluid homeostasis [8], the contribution of the lymph flow impairments to the genesis of AH has not been evaluated. Moreover, the compensatory potential of lymphatic system under pathological conditions (including cardiovascular disorders) is poorly investigated [1,2], and the information regarding hemolymphatic interactions is scarce. There is little evidence on modifications of hormonal systems and generally it does not provide any information on qualitative interhormonal interactions in AH. Although aldosterone and insulin belong to different hormonal systems, they have common targets, and Na-K exchange may be one of Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Novosibirsk Medical Institute; Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk them. In this study we investigated hemolymphatic interactions between electrolytes (Na and K), aldosterone and insulin, and their correlations in nonnoand hypertensive rats. MATERIALS AND METHODSMale normotensive rats (Wistar) and rats with genetically-determined stress-induced All (NISAG) were used. The rats weighed 180-200 g. NISAG rats were bred at the Laboratory of Evolutionary Genetics, Institute of Cytology and Genetics (Siberian Division of the Russian Academy of Sciences). Arterial pressure in stress was 205+2 mm Hg, basal level being 172+2 mm Hg. Lymph was collected from the thoracic duct under intraperitoneal Nembutal anesthesia. Blood was collected after decapitation. The contents of Na and K were determined by flame photometry in a Hitachi-180-80 spectrophotolneter. Plasma concentrations of aldosterone and insulin were determined by radioimmune assay. The results were analyzed using standard statistical methods, Student's t test, and correlation analysis.