Introduction. In the current environmental situation in Russia, the organization of early detection of cancer in women of fertile age is of particular importance, which has medical, social and demographic consequences. Among malignant neoplasms in women - breast cancer takes the first place in the Russian Federation. 30% of the cases are women of working age. The increase in the incidence of breast cancer in the Chelyabinsk region from 2008 to 2018 was about 30%. In 2018, the proportion of stage I-II breast cancer is 67.5%. To improve the quality of specialized medical care for patients with suspected and/or established breast cancer on the basis of the state medical institution «Chelyabinsk regional clinical center of Oncology and nuclear medicine» in 2018, a center for diagnosis and treatment of breast tumors (hereinafter - the Center) was established. Purpose of work. Analysis of the first results of the Center’s work. Materials and methods. Patients referred for consultation to the Center from 01.11.2018 to 31.08.2019. Results. As a result of the work of the Center for 10 months, there was a reduction in the time of examination of patients with suspected breast cancer from 30 to 14 calendar days. The share of detected breast cancer in the region at localized stages for 10 months of 2019 was higher (69.5%) compared to the same period of 2018 (66.7%), which is based on an increase in active detection of pathology in the established Center. Discussion. The creation of the Center has increased the availability of specialized care for patients with breast pathology. Reduced time for examination and conduct of trepan-biopsy of the tumor to confirm the diagnosis. Patients with breast cancer have a personalized approach to the treatment program. Conclusion. The establishment of the Center allows to improve the quality of specialized medical care for patients with suspected and/or established breast cancer.

ель исследования. В исследовании предпринимается попытка ответить на вопрос, подвержены ли риску развития отдалѐнных эффектов пациенты, неоднократно обследованные на компьютерном томографе по показаниям, связанным с диагностикой онкологической патологии, в течение последующих лет наблюдения. Материалы и методы. В качестве исследуемого эффекта рассматривалась смертность от злокачественных новообразований. Фактором риска радиационной природы считалось диагностическое облучение, полученное пациентом при прохождении компьютерной томографии. В течение периода наблюдения оценивалась кратность облучения в зависимости от возраста и других факторов. Среди обследованных лиц выделялось две группы: персонал предприятия ядерно-промышленного комплекса, в процессе трудовой деятельности подвергавшийся воздействию ионизирующего излучения от различных источников, и население, проживавшее на прилежащей к предприятию территории, не подвергавшееся его воздействию. Результаты. Получены оценки относительного риска смерти от злокачественных новообразований в зависимости от факторов радиационной и нерадиационной природы. Заключение. Результаты исследования предоставляют дополнительную информацию, необходимую для проведения многофакторного эпидемиологического анализа с целью оценки риска воздействия малых доз облучения непроизводственного характера у персонала предприятий ядерно-промышленного комплекса и населения, проживающего на прилежащей территории. Ключевые слова: КТ, МСКТ, раковый регистр, диагностическое облучение, онкологическая патология, медицинское облучение, радиогенный риск.

The aim of this study was to determine the most effective approach to the treatment of patients with continuous growth of brain glioma.Material and Methods. The study included 200 patients with progression of primary brain glioma, who were treated at the Chelyabinsk Regional Center of Oncology and Nuclear Medicine in the period from 2001 to 2021. The average age of patients was 47.86 ± 11.47 years. The ratio of men to women was 1:1. The continuous growth of high-grade glioma was detected in 125 cases. The progression of lowgrade glioma was observed in 40 patients. Transformation of low-grade glioma into high-grade glioma was found in 35 patients. Re-surgery was performed in 92 patients. Repeated radiation therapy was given to 140 patients. Chemotherapy as the method of choice was administered to 60 patients.Results. The median overall survival (OS) time was 36 months. The 1and 2-year survival rates were 96.0 % and 59.4 %, respectively. The method-specific overall survival time was 15 months. There was a tendency towards an increase in OS in all subgroups of patients who underwent re-surgery. The highest method-specific overall survival rates were observed in patients who received stereotactic radiation therapy (STRT) and combined photon-neutron therapy (CPNT): 23 and 47 months in patients with high-grade glioma and 60 and 72 months in patients with continuous growth of low-grade glioma, respectively (p>0.05). In patients with the transformation of low-grade glioma into high-grade glioma, the method-specific OS was higher in patients who received combination of chemotherapy and radiation therapy compared to those who received chemotherapy or radiation therapy alone: 32, 12, and 24 months, respectively (p>0.05).Conclusion. Repeated surgery is the optimal treatment approach for patients with continuous growth of primary brain glioma. In cases with repeated radiotherapy courses, CPNT or STRT can be the methods of choice. Treatment of patients with transformation of low-grade gliomas