BackgroundPeriodontal inflammation is characterized by injuries in collagen, epithelial, bone tissues. The hypotheses to be tested were relationship between the s100, bcl2 and myeloperoxidase in gingival tissues (MPO does affect the level of s100, bcl2). The object of this study was to investigate of s100 expression, bcl2 expression and myeloperoxidase expression in periodontal inflammation.Methods27 patients (giant-cell epulis) and 30 patients (acute and chronic inflammations) were included in the study for s100 expression, bcl2 expression and myeloperoxidase expression by immunohistochemistry and hematoxylin - eosin.ResultsGiant-cells in epulis positivity for myeloperoxidase has been observed in 100 % However, only 75.31 % of giant-cells were positive for bcl2 expression. Acute 98.2 %, and chronic 89.28 % inflammation was a significant positive for myeloperoxidase. The immunohistochemical findings of s100, bcl 2 and myeloperoxidase in epithelial layers have showed the result of 100 %, 82,2 %, 100 % positive cells in acute and 100 %, 78.25 %, 100 % in chronic process of inflammation respectively.ConclusionThe results indicate that the pathogenesis of periodontal inflammation might involve inhibition of cell death, through the overexpression of bcl-2, due to identifying factors myeloperoxidase (result in the DNA damage by the product of catalysis). The highest levels of s100 activity have been found at sites with chronic inflammation.

Aim of the study. To investigate the expression of CD68 and HSP90AA1 in periodontal inflammation. Methods. A total of twenty-seven patients (giant-cell epulis) and thirty patients (acute and chronic inflammations) have been examined for expression of CD68 and HSP90AA1 by hematoxylin – eosin and immunohistochemistry. Results. Strong giant-cell positivity for CD68 was observed in 100% of patients whereas only 85.31% of giant-cell was positive for HSP90AA1 (p lower than 0.05). Strong macrophage immunoreactivity for CD68 was figured in acute 23.2±1.3%, and in chronic 83.1±5.6% (p lower than 0.05) inflammation. Immunoreactivity for HSP90AA1 was fixed in acute and chronic inflammation 98.2±1.79%. Conclusion. Inflammatory macrophages are a group of cells with protective functions, macrophages being more set up in chronic inflammation. Central giant cell epulis is the multinucleated macrophages, formed as a result of chronic inflammation. Population of macrophages resulted in bone resorption.