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Problem statement: An automated software package is developed for quantifying Luteinizing Hormone (LH) release from pituitary gonadotropes in response to short pulses of gonadotropin-releasing hormone (GnRH). Approach: These computer programs were designed to accommodate the release mechanism that consists of three stages, namely; (1) Production of different concentrations of effectors (such as receptor-hormone binds, G protein interactions, inositol 1,4,5-trisphosphate IP 3 ), (2) Release of Ca 2+ from the endoplasmic reticulum ER and finally (3) Release of LH through pumping of Ca 2+ in and out of the cytosol. Results: The programs were coded in C++ computer language and implemented on Pentium PC. The designed model was intended to help in explaining the characteristics of LH release in response to various duration and different concentrations of GnRH pulses in the presence and absence of external Ca