This publication gives brief information about the system of reference materials (RM) in the Russian Federation, particularly in the field of legal and regulatory support for the production and use of RM. The role of the State service for reference materials of composition and properties of substances and materials is discussed along with the components of state regulation in view of formation of the national market of reference materials. The aspects of «search» for RM that are necessary for implementation of the measurement tasks assigned to the laboratory are shown. The information about large producers of RM in metallurgy, nuclear energy and geology is presented.

The article presents the results of researches used as the basis of development of metrological assurance of measurement results of microbial transglutaminase content in samples of nutritive products complex that meets the requirements of the legislature in the field of assurance of measurement uniformity. The complex includes certificated measurement procedure that confirmed its applicability for samples of dairy and fish products according to the results of interlaboratory tests. The experience of preparation of homogeneous and stable samples of nutrition containing microbial transglutaminase and which will be used as a developing base of certified type reference material is described. The difficulties that were appeared during the carried out works by specialists from UNIIM -Affiliated Branch of the D. I. Mendeleyev Institute for Metrology and «XEMA» LLC at the time of solving the issue on application of the attested procedure of measurement when confirming the conformity of products with the requirements of the Technical Regulations of the Customs Union TR TS029/2012.