Проведено клинико-экспериментальное исследование для выявления морфологических изменений в спиральном органе животных и возможности воздействия на морфологический субстрат заболевания у лиц с тугоухостью, обусловленной виброакустическим воздействием. В эксперименте участвовало 34 белых беспородных крысы. Клиническая часть включала аудиологическое обследование 127 железнодорожников. В эксперименте выделена группа интактных животных, группа крыс, подвергшихся воздействию шума и вибрации на фоне иммобилизации без лечения, группа крыс, подвергнутых тому же воздействию, но с одновременным лечением препаратом с сосудистым эффектом силденафил и группа крыс с тугоухостью, которые получали лечебный препарат отсроченно. Морфологические исследования улиток височных костей животных свидетельствовали о дистрофических изменениях в спиральном органе, признаках апоптоза клеток внутреннего уха и спирального ганглия. Медикаментозная терапия силденафилом была более эффективна при применении одновременно с воздействием и приводила к уменьшению выраженности морфологических изменений. У больных с сенсоневральной тугоухостью прием силденафила вызывал протективный эффект, сопоставимый с использованием традиционных лекарственных средств. Ключевые слова: сенсоневральная тугоухость, шум и вибрация, акувибрационное воздействие, работники железнодорожного транспорта, моделирование тугоухости, морфологические нарушения в спиральном органе, лечение тугоухости.

Theoretical and methodological foundations of research of communicative processes in a selfmanaged work team are considered in the paper. The self-managed work team has been studied as a form of organisational self-management. Communication processes act as a foundation of management of social relations. Therefore, the study of communication processes is connected with the change of the structure of the team, the structure of communication, decentralization and complexity of tasks of selfmanaged work teams, which implies the necessity of free access to information and effective exchange with it. Analysis is conducted based on the study of models of teams, models of communication processes, as well as materials. The empirical sociological study is undertaken in the company "Lubimyi Krai" in 2009-2016. The paper includes a characteristic of the study; an interdisciplinary approach underlies the study. The purpose of the paper is to reveal the peculiarities of communication processes in the self-managed work team and to develop the directions of improvement the activity of self-managed work teams. General scientific methods and the methods of concrete-sociological studies are used in the paper. The authors of the paper provide analysis of the findings. It is possible to conclude that it is necessary to improve the process of introduction and formation of self-managed work teams as a form of organisational self-management, the programmes of lifelong coeducation of employees and tutorship, which allow involving the participants of the work team in the production of sociocultural models of behaviour.

Aim: to study impact of acute somatic pain on lysozyme activity of different ages rats: newborn, rats after eye opening, month of age rats, adult and old rats. Methods: Lysozyme activity determined before pain irritation and after 2, 30, 60, 120, 180 min using Dorofeychuk’s method in our modification. Pain effect was modeling by electrical stimulation. Results: activity of lysozyme was 0.434±0.01 units in intact newborn rats, it was higher than in adult rats — 0.260±0.01 units (p 0.001) and it was unchanged during the experiment. We found low lysozyme activity in ratsafter eye opening — 0.015±0.003 units and it was stable during the experiment. Month of age rats had diphasic reaction: lysozyme activity was 0.191±0.01 units in intact rats, it increased up to 0.378±0.01 units (p 0.001) in 2 min after painful irritation and it decreased up to 0.113±0.02 units (p 0.001) in 30 min. Lysozyme activity was 0.260±0.01 units. Single-phase reaction was determined after acute painful irritation: increase of lysozyme activity after acute somatic pain up to 0,450±0,014 units (p 0.001). Lysozyme activity was 0.246±0.02 units inblood plasma of old rats. It decreased up to 0.170±0.01 units (p 0.01) after painful irritation and it was 0.387±0.01 (p 0.001) in the end of the experiment. Conclusion: Response on pain irritation has differences in different groups. The common vector of response reaction after pain was the increase lysozyme activity in month of age rats, adult rats, rats after eye opening and old rats. Reaction of increasing lysozyme activity the most expressed in adult rats. The data are considered as a preventive readiness of lysozyme to answer on damage and infection.