The purpose of the research in the article is to study a specific infectious disease – hemophilous polyserositis of pigs, its spread in the territory of the Ural region. Epizootological analysis of Piglet morbidity was shown, laboratory studies were conducted, and recommendations for the treatment and prevention of this disease were made. Evaluation of the specific effectiveness of the plant - tissue immunomodulator “Vidoral” in the treatment of hemophilous polyserositis in pigs and increasing the protective activity of vaccines. The features of the development of the epizootic process in hemophilous polyserositis of pigs in the studied agricultural enterprises of two regions of the Ural region are characterized. The role and place of porcine hemophilous polyserositis among respiratory diseases of infectious etiology in the formation of the nosological profile of infectious pathology is determined. The drug Vidoral on a plant and tissue basis was theoretically justified and studied, and the effectiveness of its use in animals with hemophilous polyserositis in pigs was determined.

According to current concepts, ruminal and metabolic acidosis occur due to feeding cattle mainly with preserved acidic feeds such as silage and haylage. However, errors in feeding are not the only etiological factor leading to acidosis. In some cases, metabolic acidosis in cattle can develop along with respiratory infection caused by viral and bacterial agents. The main pathological processes resulting from acute respiratory diseases of cattle are bronchitises, tracheites and pneumonias. When the respiratory tract is affected in cattle, hypoxia occurs, causing intoxication and, thus, leading to ruminal acidosis. As a result, vasoactive substances (bacterial endotoxins, histamine, lactate) enter the bloodstream, the vascular endothelium is damaged due to the simultaneous expansion of arterioles and compression of venules, blood fluid is perfused from the vessels into the surrounding tissues, the blood flow in the microcirculatory bed is disrupted. An important role in the disturbance of blood circulation in small blood vessels is played by circulating immune complexes representing the «antigen-antibody» complex. Low molecular weight circulating immune complexes settle in various organs and tissues of the body, lead to inflammation and damage the normal tissue structure. Most frequently, immune complexes affect the endothelium of blood vessels, renal glomeruli and joints. Distal limb vessels are primarily affected in cattle, leading to disturbance of skin trophism of the limbs and hooves, development of laminitis, while the hoof horn is weakly keratinized and cannot resist aggressive mechanical and chemical environmental factors. Damaged hooves are the gateway of infection for the agents of necrobacteriosis (Fusobacterium necrophorum), staphylococcosis (Staphylococcus spp.), streptococcosis (Streptococcus spp.) and other pathogens. In addition, favorable conditions evolve for the development of mixed infection due to reduction in the overall organism resistance, which is observed for both respiratory and distal limb infections.