VACCINE PROPHYLAXIS OF PNEUMOCOCCAL INFECTION AMONG PREMATURE INFANTS WITH BRONCHOPULMONARY DYSPLASIA Introduction. Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease among children of the first year of life, especially children born prematurely with extremely low and very low body weight. Material and methods. To estimate the number of children born alive in Perm Territory between 2015 and 2017, official statistics data were used. Experimental epidemiological studies were used to assess safety, reactogenicity, immunogenic activity and preventive efficacy of the Prevnar 13 vaccine when immunizing preterm infants with bronchopulmonary dysplasia under prospective controlled randomized clinical observation. Results. There were 29 premature infants with bronchopulmonary dysplasia under observation, the control group comprised 29 unvaccinated premature infants with BPD and 30 full-term infants. The PCV 13 vaccination of preterm infants with BPD established good tolerance, poor reactogenicity (17.2±0.57%) and vaccine tolerance like full-term infants (16.5±0.55%), high safety profile, high immunogenic properties (seroconversion-93.1%, seroconversion factor-5.5). Evaluation of immunogenic activity among children with BPD vaccinated with the PCV 13 vaccine revealed high immunological efficacy compared to unvaccinated healthy children. Conclusion. The need for vaccination of premature babies with BDL against pneumococcal infection has been scientifically substantiated. The study has confirmed safety, poor reactogenicity, high immunogenic activity and preventive efficacy of the Prevenar 13 vaccine among premature babies with BDL under the conditions of the catamnesis department of the perinatal center within the follow-up monitoring of vaccinated infants over three years. Cuvinte cheie: vaccin VPC13, infecție pneumococică, displazie bronhopulmonară. VACCINOPROFILAXIA INFECȚIEI PNEUMOCOCICE LA SUGARII NĂSCUȚI PREMATUR, DIAGNOSTICAȚI CU DISPLAZIE BRONHOPULMONARĂ Introducere. Cea mai frecventă boală pulmonară cronică la copii în primul an de viață, în special la sugarii născuți prematur, cu o greutate corporală foarte mică, este displazia bronhopulmonară (DBP). Material și metode. Pentru a estima numărul copiilor născuți vii în perioada 2015-2017, în regiunea Permi, Rusia au fost utilizate datele statistice oficiale. Au fost proiectate studii epidemiologice experimentale pentru evaluarea eficacității profilactice și a reactivității, demonstrarea siguranței și activității imunogene a vaccinului pneumococic conjugat (VPC 13) la imunizarea sugarilor născuți prematur cu DBP. Rezultate. Au fost investigați 29 de copii născuți prematur, diagnosticați cu DBP și pentru comparație-29 de copii născuți prematur, nevaccinați cu DBP și, respectiv, 30 de copii născuți la termen. Vaccinul VPC 13 administrat la sugarii născuți prematur care suferă de DBP a stabilit o toleranță bună, reactivitate scăzută (17,2±0,57%) și toleranță similară la vaccin ca și la copiii născuți la termen (16,5±0,55%), siguranță înaltă, propriet...

Abstract. The hepatitis A has important social and economic significance in the Russian Federation now. The analysis of multiyear dynamics of hepatitis A incidence in the regional center — Perm city has been carried out. It was established that vaccination of children against hepatitis A within the different institutions influenced on the intensity of epidemic process. The hepatitis A incidence rates significantly decreased in the vaccinated groups and in the whole population. The typical seasonal distribution of cases and their clustering became less manifested.

Background. The most frequent chronic lung pathology among infants and especially in premature children with extremely low and very low body weight is bronchopulmonary dysplasia (BPD). The aim of the study is to study the prevalence of bronchopulmonary pathology among premature children and justify the need to vaccinate against pneumococcal disease premature children suffering from BPD. Methods. The official statistics (Form №32) and data from annual reports of the catamnesis department of “the Honourary order” Perm Regional Clinical Hospital were used in order to measure the number of premature children born alive in Perm region in 2015-2017 yy. The estimation of prophylactic efficacy and reactogenicity of 13-valent pneumococcal conjugate vaccine (PCV13) at immunization of premature children with BPD. Results. The study group included vaccinated premature children with BPD (n=29), the experimental group included non-vaccinated premature children with BPD (n=29) and 30 vaccinated term children. Administration of PCV13 in premature children suffering from BPD has revealed its high prophylactic efficacy (no cases of community-acquired pneumonia among vaccinated children during the prospective study for 3 years), high tolerability (no cases of broncho-obstructive syndrome or negative effects on respiratory system such as apnoea or desaturation among vaccinated children). Low reactogenicity (17.2 ± 0.57%) and similar vaccine tolerance with term children (16.5 ± 0.55%) has been revealed as well. The combination of PCV13 with other vaccines from immunisation schedule did not increase the number of vaccine-induced diseases in comparison with administration of PCV13 alone. Conclusion. The scientific necessity of vaccination of premature children with BPD against pneumococcal disease has been proved. The high prophylactic efficacy and low reactogenicity of PCV13 in this children group at tertiary neonatological care (catamnesis department of perinatal center) has been established within the national immunisation schedule.