HFEW represents a novel technique for retinopexy during vitreoretinal surgery. It allows firm chorioretinal adhesion immediately after exposure. In non-vitrectomized eyes, using 14-16 V is particularly effective.

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PurposeTo determine the efficacy of intravitreal aflibercept injections for the treatment of patients with choroidal neovascularization (CNV) associated with pathologic myopia.MethodsIn this uncontrolled, prospective cohort study, 31 eyes of 30 consecutive patients affected by CNV associated with pathologic myopia were treated with intravitreal aflibercept (2 mg) as needed following two initial monthly doses and observed over a 12-month follow-up period. The primary endpoint was change in best-corrected visual acuity (BCVA) at month 12, while central retinal thickness (CRT) on optical coherence tomography (OCT), neovascularization activity on fluorescein angiography, the number of aflibercept injections administered, and safety were examined as secondary endpoints.ResultsPatients received a mean of 2.6 intravitreal aflibercept injections over the 12-month study period. Compared with baseline, BCVA improved significantly at all time points (P<0.05). Mean (standard deviation [SD]) decimal BCVA was 0.2 (0.1) at baseline and 0.35 (0.16) at month 12. The greatest improvement in BCVA was seen within the first 2 months (P=0.01). Mean (SD) CRT on OCT decreased from 285 (62) µm at baseline to 227 (42) µm (P=0.01) at month 12. There was a continuous decrease in mean CRT on OCT over time. No cases of endophthalmitis, uveitis, stroke, or retinal detachment were noted. No patient demonstrated an intraocular pressure >20 mmHg during any study visit.ConclusionThe 12-month results of intravitreal aflibercept for myopic CNV using an as-needed regimen were positive, showing benefits in visual and anatomic outcomes and an acceptable tolerability profile.

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It remains poorly understood what should be the temperature of the irrigating solution for intraocular surgery and how long it is reasonable to use irrigating solutions during vitrectomy. Purpose: To investigate the structure of the rabbit chorioretinal complex after vitrectomy with the use of irrigating solutions having different temperatures for 30 minutes. Materials and Methods: Twelve Chinchilla rabbits (24 eyes) were divided into two experimental groups and one control group. The two experimental groups, each of 5 rabbits (10 eyes), underwent a three-port pars plana vitrectomy with either 22°C or 5°C irrigating solution. Two intact rabbits (4 eyes) were used as controls for comparison. The duration of irrigation/aspiration was 30 minutes. The material for histology was obtained at days 1 and 7 after surgery, and the chorioretinal complex was histologically examined by light microscopy. Results: Groups of animals subjected to thirty-minute vitreous cavity cooling with the 22 °C or 5°С irrigating solution showed no structural changes in the retinal and choroidal components compared to intact animals. Conclusion: The 22 °C or 5°С irrigating solution produces no structural changes in the retina and choroid, and can be used in the vitreoretinal surgical procedure for continuous vitreous cavity irrigation lasting for up to 30 minutes.