Researches to study the milk productivity dependence of Ukrainian Red-and-White dairy cows on genotypic and paratypic factors were conducted in the breeding farm PAE "Piskivske" Bakhmach district of Chernihiv region. The most representative five genotypic groups of animals divided by the conditional share of heredity of Holstein breed were studied: I - livestock with a share of blood 50.01-56.25; II - 56.26-62.50; III - 62.51-75.00 and IV - 75.01-87.50; V - 87.51% and <. By comparing different genotype groups of cows installed dependence of yield amount on conditional share of inheritance Holstein breed. With the growth conditional proportion of Holstein blood, milk yield increased during the evaluated first three and higher lactations. The high and reliable effect was found on the yield amount of cows firstborn by factors of birth (  = 0.329) and calving (   = 0.336). The share of birth and calving season influence on milk yield although insignificant but reliable and amounted to 3.7 and 5.3%, respectively. The value of milk yield of cows firstborn in the controlled herd greatly depended on the sire genotype (  = 0.315), cow's conditional blood by Holstein breed (  = 0.264), father breeding value (   = 0.335) and mother cow's father (  = 0.340), paternal (   = 0.163) and maternal line (   = 0.089). According to research results was substantiated expediency of monitoring selection information, identification and use of animal-specific patterns of leading traits development of milk productivity depending on the geno-  and paratypic factors influence in the selection process of pedigree herd formation.