Clinico-epidemiological characteristics of parvovirus В19 infection are presented. Especially dangerous is the virus for pregnant women in the first and second trimesters of pregnancy, as it can lead to spontaneous abortion, the development of non-immune dropsy or intrauterine fetal death. Infectious erythema is characterized by a bright erythema of the cheek skin — a symptom of «spanked» cheeks, a patchy-papular «lacy» rash on the skin of the trunk and extensor surfaces of the extremities, more common in children aged 4 to 10 years. Diagnosis of parvovirus infection B19 is based on the results of serological methods, PCR, detection of IgM, immunoblot IgM/IgG. A clinical case of infectious erythema in a girl of 5 years is described.