Aim. To study the functional state of arterioles in patients with type 2 diabetes mellitus and concomitant arterial hypertension (AH) and evaluatethe role of sodium in mechanisms of elevation of arterial pressure (AP) in this pathology. Materials and methods. 163 patients of whom 83 had DM2 with AH and 80 essential hypertension. They were examined by dopplerography of themicrocirclatory bed, measurement of arterial blood flow and daily sodium urinary excretion. Results. Patients with essential AH showed increased arteriolar circulation rate and enhanced reactivity of microvessels. These parameters werereduced in patients with DM2 and AH who consumed large amount of table salt. Conclusion. Mechanisms of development of essential AH and AH in DM2 are significantly different.

The aim: to detect the presence of pathoautokinesis signs in development and maintenance of hyperlipoproteidemia (HLP) in experiments on intact rabbits and the rabbits after long-term intravenous injection of lipoproteids (LP).Material and methods. 3 series of experiments on rabbits which received for 60 days intravenous homologous apo-Bcontaining LP (25–30 mg LP per 1 kg of the body mass) were carried out. Correspondence of calculated and true values of injected LP, duration of HLP maintenance after LP injection termination and the body response to single injection of interlipin as well as character of elimination with J 131 apo-B-LP from blood alteration of the liver homogenates have been studied.Results. It has been shown that in 50% of rabbits with experimental HLP, the true values of intravenously injected LP were higher than calculated ones. In rabbits after LP injection termination HLP arisen lasts for 30–40 days and intralipid injection induces prolonged HLP. The values of radioactivity of plasma LP in HLP testify to their difficult elimination from blood and their accumulation in the liver.Conclusion. Mechanisms of pathoautokinesis are present in HLP development and maintenance.