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The aim of the article is the nosogeographic assessment of the adult population morbidity of the Sumy region during 2009–2019. The assessment was made by primary morbidity and prevalence of cardiovascular, respiratory diseases as well as oncological pathologies. There is a tendency towards a decrease of diseases prevalence as well as primary morbidity of above mentioned diseases among the adult population of the Sumy region in 2019 as compared to the “top” indicators in 2016 and 2017. The prevalence of diseases among the region’s population in 2019 decreased by 9.72 % and 9.40 % compared to 2016 and 2017, respectively, while the primary morbidity rate decreased by 13.9% and 10.29%, respectively. The indicators of diseases prevalence and population primary morbidity by cardiovascular diseases and neoplasm which are basic causes of mortality in Ukraine, as well as the European Union were analyzed. During the last 10 years highest indicators of prevalence of the cardiovascular diseases were registered in 2018 (57, 459.63 cases per 100 000 people) and primary cardiovascular morbidity – in 2016 (4 394.71 cases per 100 000 people). Prevalence of neoplasm among the Sumy region’s inhabitants for the last 10 years increased by 29.59 % and in 2019 was 6 126.43 cases per 100 000 people. At the same time the primary morbidity increased by 6.18 %. Respiratory diseases occupy the 1st place in the structure of primary population morbidity, the 2nd place – in structure of prevalence of the diseases); its highest indicators were observed in 2016. The index of accumulation of the diseases (the ratio between prevalence of diseases and primary morbidity) among the Sumy region population and by administrative-territorial districts was identified. To realize the nosogeographic assessment of the adult population of the Sumy region and to highlight the groups of the administrative-territorial districts of the Sumy region by the characteristics of population morbidity the cluster analysis procedure was used. The first cluster includes the Sumy and Seredyna- Buda districts. The second cluster was formed by 6 administrative-territorial districts of the region: Yampil’, Hlukhiv, Trostianets, Krasnopillia, Shostka and Velyka Pysarivka districts. The third cluster united both Romny and Buryn’ districts. The fourth cluster includes most of administrative-territorial districts of the region: Lypova Dolyna, Nedryhailiv, Lebedyn, Krolevets, Konotop, Putyvl’, Okhtyrka and Bilopillia districts. The fifth cluster is represented by the regional center – the city of Sumy.