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Modern industrial poultry farming occupies a leading position in the production of dietary foods, for which it is appropriate to use biologically active substances and probiotics. The study compared the effectiveness of compound feed with the addition of sodium selenite, bio-nano-selenium and L. plantarum in terms of body weight, weight gain, feed consumption and safety of experimental quail. The quails of the Pharaoh meat breed were kept in the vivarium of Bila Tserkva National Agrarian University and by the method of analogues were divided into 4 groups - control and three experimental ones. The duration of the study was 35 days. The results of the study indicate that the use in the quail’s diet of probiotics (L. plantarum) and selenium preparations (sodium selenite and bio-nano-selenium) leads to a predominance of poultry experimental groups in live weight over control analogs. It was found that the growth of bird’s live weight during the experiment differed depending on the use of the Selenium medication or probiotic, and the most intense effect on live weight of quails was the use of bio-nanоselenium in the diet of poultry (11.8% at the end of the experiment). Changes in absolute and average daily body weight gains of experimental birds have been clarified. The use of sodium selenite in the diet of quail caused a tendency for an increase in gains compared with control analogs at the beginning of the study and a downward trend during the fifth week of the study. It was found that the use of probiotics and bio-nano-selenium caused an increase in quail growth, which was more pronounced and reliable when feeding bio-nano-selenium. The obtained results show that probiotic and selenium preparations reduce feed consumption by 1 kg of weight gain, body weight increase by 3.05–11.8% and by 3.3–6.6% increase the safety of the experimental livestock with the best indicators in the group, receiving bio-nano-selenium.

The aim of this work was to investigate the toxicity of selenium preparations and probiotic by intragastric administration to laboratory animals, weight coefficients of internal organs of white rats, haematological parameters of white rat blood on the 30 th day of the experiment. During the experiment, 3 groups of white rats were formed, which received sodium selenite with probiotic and bionanoselenium for a month at doses of fed compound 1000, 3000 and 5000 mg/kg. We took into account such indicators of animals as appearance, behavior, condition of hair, visible mucous membranes, attitude to food, rhythm, respiratory rate, time of onset and nature of intoxication, its severity, course, time of death of animals or their recovery. Studies had shown the absence of animal's deaths or diseases with intragastric use of the studied compounds, which allows to classify them as toxicity class 4 -low-toxic substances. At autopsy, no pathological changes in the internal organs of the thoracic and abdominal cavities and no significant changes in the weights of the liver, heart, lungs and kidneys, compared with the control group, with 30-day use of the studied supplements with simultaneous weight gain of the spleen. No signs of inflammation, circulatory disorders and trophism were found in the parenchymal organs. Long-term admission of the studied drugs caused a probable increase in hematological parameters (hemoglobin concentration, number of erythrocytes and leukocytes, hematocrit) in the experimental animals. The conducted primary toxicological study is the basis for the development and use of low-toxic, effective and environmentally friendly drugs for industrial poultry and livestock that do not cause side effects.

The article presents the results of monitoring the productive and biochemical indicators of the growth rate of young clary catfish using dry extruded complete feed for fish, which have proven to be best adapted for use at all stages of growing clary catfish, namely: Skretting and Roycher AQUA in experimental conditions. The research was conducted in the educational and experimental laboratories of Bila Tserkva National Agrarian University from 2019 to 2021. For the experiment, we used the young of the African marble clary catfish (Clarias gariepinus), purchased from one of the fish farms in the Odesa region. Clary catfish fry was kept in four rectangular plastic containers for 90 liters of freshwater. The tanks were two-thirds full (60 liters). The water temperature was maintained at 26 °C. For the experiment, 120 fries were used, which were kept in four plastic tanks by the method of analogs of 30 specimens each. Given that the fry differed in weight (for experiment 1 we selected fry with higher weight, and for experiment 2 – with lower weight), they were divided on the principle of analogs into two experimental and two control groups. Based on the results of monitoring in Experiment 1, fish observations, and mathematical calculation, we found that the feed ratio when fed Skretting and Roycher AQUA starter feed is 0.74 and 0.99 %, respectively. Based on the results of monitoring, fish observations, and mathematical calculation, it was found that the feed ratio in experiment 2 when feeding starter feed Skretting and Roycher AQUA is 0.75 and 1.54 %, respectively. The high feed rate for the use of Roycher AQUA can be explained by overuse due to the grinding of the granules. Growing aquaculture facilities in an artificially formed system – production, allows you to get environmentally friendly fish products all year round. This is a very important criterion in modern environmental conditions.

The Ros River is polluted with heavy metals, petroleumproducts and organic matter due to the activities of variousindustries, including agriculture (washing away pesticides and fertilizers), food, light and petrochemical industries, etc.Intake of drinking water in Bila Tserkva district is carried outfrom the river Ros, so the aim of the work was to systematizethe results of research over the past 10 years and identify thedynamics of changes in the ecological state of the river.Object of research: Ros River within Bila Tserkva district of Kyiv region.Subject of research: negative environmental factors,water quality indicators. The study of the state of the question was carried out by methods of analysis and synthesis.Water quality assessment was conducted in the Ros Riveron a monthly basis. Initial data (monthly results) are averaged by seasons: spring (March-May, 2010-2020), summer(June-August, 2010-2020), autumn (September-November,2010-2020), winter (December of the previous year - January, February of the current year, 2010/2011-2020/2021).Among the studied indicators there are ammonium salt, nitrates, nitrites, chemical oxygen demand (COD), biochemicaloxygen demand (BOD5), phosphates, total iron, manganese.Seasonal concentrations throughout the study period for ammonium salt ranged from 0.11 to 2.17 mg/dm3, nitrites – from0.01 to 0.82 mg/dm3, nitrates did not exceed 40.0 mg/dm3,COD– in the range from 15.9 to 61.1 mg/dm3, BOD5– in therange from 1.5 to 8.3 mg/dm3, phosphates – from 0.05 to 0.49mg/dm3. Excess concentration of total iron and manganesewere observed in 59% and 29% of cases, respectively. Thatis, there is a tendency to deterioration water quality by somecomponents; the main reason for this is anthropogenic activity, namely the inconsistency of water treatment equipmentof economic entities with modern environmental standardsand the presence of unidentified sources of discharges intothe Ros River basin. Key words: Rosriver, hydrochemical indicators, ecological condition, seasonal values, MPC.