Х роническую сердечную недостаточность (ХСН) у пациентов с сохраненной фракцией выброса (ФВ) левого желудочка (ЛЖ) справедливо называют терапевтической загадкой. Это обусловлено совокупностью многообразия патофизиологических звеньев формирования данного феномена. Прежде всего, это нарушение релаксации и вентрикуло-сосудистого сопряжения, хронотропная несостоятельность объемно-емкостные нарушения и дисфункция эндотелия. В настоящее вре-мя не существует четкой стратегии как диагностики, так и фармакологической и нефармакологической коррекции проявлений ХСН с сохраненной ФВ ЛЖ. В значительной мере это, скорее всего, мультидисциплинарная и долговременная в решении проблема [1]. Впервые диастолическая сердечная недостаточность была описана в 1982 г. [2], в 80-90-е годы XX века велись серьезные дискуссии по вариантам диастолической ХСН (ДХСН), что, прежде всего, было обусловлено бурным

The physicochemical action of solutions of surfactants on coal is utilized during its recovery in order to reduce the dust-forming capability and dust-suppression [I], in combating sudden coal and gas ejections [2], degassing [3], for hydraulic rupture of strata and control of the state of the rock mass [4], for dispersion of the coal [5][6][7]. Lyophylization of the coal surface occurs during its interaction with adsorption-active solutions, and consequently, a diminution in the interphasal surface energy resulting in a change in the strength properties of the coal [8]. At the same time the elastic characteristics of the coal substance change. However, features ~,f the change in strength and deformation properties of coal during the action of adsorption-active media, especially under the conditions of a complex stress state, are not always evident and, consequently, cannot be taken adequately into account when performing work utilizing the physicochemical treatment of rock masses and coal in order to increase the safety and efficiency of mining production processes. Taking into account the importance of such data for intensification of the change in properties and state of the host rock during mining, including even finding the optimal condition~ for coal destruction, we studied the singularities of adsorption-active fluid interaction with coal under complex stress state conditions.The deformation curves for brown coal (a) and coal of grade T (b) obtained under simple uniaxial compression conditions are represented in Fig. i. Mixtures of aqueous solutions of cation-active surfactant katamine and the nonionogenic wetting agent DB (0.1% by volume concentration) were used for the brown coal, and mixtures of anion-active surfactants (isopropyl alcohol, 10% by volume) and the wetting agent DB for the coal of brand T. When the process of impregnating the coal specimen agrees, in time, with the load increase (curves 3 and 4), the strength of the coal under uniaxial compression diminishes by more than three times. The elastic modulus does not change here.If adsorption-active solutions interact with coal from the be~innin~ at minimal loads that only prevent the possibility of deformation while swellin~, then the strength of the coal under subsequent loadin~ will diminish less than in the previous case. The elastic modulus of the specimen diminishes four times and the deformation process acquires a plastic nature (curves 5 and 6).The behavior of coal in the complex stress state under the action of surfactant solutions was studied by the method described in [5,6]. The kind of stress state on the free surface and at the middle point of a cubic specimen was estimated by the magnitude of the Nadai--Lode parameter, the work of the deformation was determined by the magnitude of the principal stresses produced under triaxial compression and the elastic modulus of dry specimens.Filling of the sorption space of coal under complex stress state conditions will depend not only on the degree of molecular interaction between the adsorp...

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The research is devoted to the evaluation of the depressor and constrictive components of the vascular reactiveness in the people with burdened heredity on atherosclerosis and the factors of risk of this disease’s development. The connection of the vascular reactiveness of peripheral arteries with the factors of risk of atherosclerosis development is discovered. The results of researches allow to suppose that atherogenic factions of lipoproteins, inflammatory cytokines produced by mononuclear of nitric oxide participate in the formation of pathological vascular reactions in people with atherosclerosis and with burdened atherosclerosis heredity on preclinical disease level.