The primary aim of the study is assessment of hair and whole blood trace element and mineral levels in children living in a polluted area near a copper smelter (Karabash) and two control locations (Varna, Tomino) using inductively coupled plasma mass spectrometry. The obtained data indicates that both blood and hair As, Pb, and Fe levels in children living in Karabash significantly exceeded the control values. Whole blood levels of copper in children living in Varna exceeded that in Tomino (p = 0.155) and Karabash (p < 0.001) by 16 %. Oppositely, hair concentration of Cu was maximal in children from Karabash. Blood Ca and Mg content in children from Varna exceeded the respective values from Tomino and Karabash by 32 % (p = 0.021) and 42 % (p < 0.001), and 19 % (p < 0.001) and 9 % (p < 0.001), respectively. Similar differences were observed in hair mineral content. Oppositely, children living in Tomino and Karabash were characterized by 10 (p = 0.002) and 23 % (p < 0.001) higher levels of blood phosphorus. At the same time, hair P content was maximal in a polluted area. Therefore, children living in a polluted area near a copper smelter had significantly higher values of heavy metals and decreased Mg and Ca content in biosamples. It is supposed that adverse health effects in persons living near a copper smelter may be associated not only with toxic metal overexposure but also with altered mineral homeostasis.

Развитие технологий выхаживания детей, родившихся недоношенными, с очень и экстремально низкой массой тела оказывается позволяет позволяет кардинальным образом улучшить результаты выхаживания новорожденных. Выжившие новорожденные из группы перинатального риска имеют груз проблемных отклонений состояния здоровья и развития. Комплексное мультидисциплинарное катамнестическое наблюдение – эффективная форма организации медицинской помощи детям раннего возраста с заболеваниями перинатальной патологии находящихся в группе риска по развитию негативных отдаленных последствий. С 2019 г. в Челябинской областной детской клинической больнице создана многоуровневая мультидисциплинарная система оказания медицинской помощи детям из групп перинатального риска. Система работает, набирает обороты, дает заметные результаты, увеличивается численность наблюдаемого контингента. Целью катамнестического наблюдения за детьми группы перинатального риска является профилактика отдаленных последствий перинатальной патологии, снижение уровня хронических заболеваний, инвалидности с детства и смертности. The development of technologies for nursing children born prematurely with very and extremely low body weight turns out to make it possible to radically improve the results of nursing newborns. Surviving newborns from the perinatal risk group have a burden of problematic health and developmental abnormalities. Comprehensive multidisciplinary follow-up observation is an effective form of organizing medical care for young children with diseases of perinatal pathology who are at risk for the development of negative long-term consequences. Since 2019, a multi-level multidisciplinary system for providing medical care to children from perinatal risk groups has been created at the Chelyabinsk Regional Children's Clinical Hospital. The system works, gains momentum, gives noticeable results, the number of the observed contingent is increasing. The purpose of follow-up monitoring of children at perinatal risk is to prevent long-term consequences of perinatal pathology, reduce the level of chronic diseases, childhood disability and mortality.

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